HitPredict

Interactor 1: SH2B3 (P50745)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Interactor 2: SH2B1 (Q62985)
SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
Gene: SH2B1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22028877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 368 Rn			1 756
+	Hs
		1224936 SH2B3_HUMAN (64-359): 5.78e-64: 215: 67.11		TENS2_HUMAN (77-743): 2.53e-82: 288: 12.88
+	Hs
		463474 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		BTK_HUMAN (310-701): 1e-64: 229: 12.97
+	Hs
		439905 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		LCK_HUMAN (388-699): 5.27e-65: 226: 16.04
+	Hs
		439906 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		LCK_HUMAN (388-699): 5.27e-65: 226: 16.04
+	Hs
		440246 SH2B3_HUMAN (64-359): 5.78e-64: 215: 67.11		LCK_HUMAN (388-699): 5.27e-65: 226: 16.04
+	Rn
		1057709 LYN_RAT (8-357): 9.83e-66: 218: 15.78		LYN_RAT (404-701): 1.69e-62: 219: 14.47
+	Hs
		462946 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		LYN_HUMAN (404-701): 9.67e-62: 218: 13.82
+	Hs
		462963 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		SRC_HUMAN (391-701): 3.91e-61: 216: 12.54
+	Hs
		463278 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		LYN_HUMAN (404-701): 9.67e-62: 218: 13.82
+	Hs
		462945 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		YES_HUMAN (375-704): 1.66e-60: 215: 14.45
+	Hs
		463286 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		HCK_HUMAN (372-701): 1.47e-61: 217: 14.88
+	Hs
		463302 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		SRC_HUMAN (391-701): 3.91e-61: 216: 12.54
+	Rn
		1057713 LYN_RAT (8-357): 9.83e-66: 218: 15.78		SRC_RAT (390-701): 1.42e-59: 212: 12.99
+	Hs
		463388 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		TEC_HUMAN (291-701): 2.16e-57: 208: 13.74
+	Hs
		440300 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		FYN_HUMAN (394-701): 1.82e-56: 204: 13.64
+	Hs
		463000 YES_HUMAN (80-328): 3.81e-65: 217: 15.58		SHC1_HUMAN (378-616): 1.62e-51: 191: 23.01
+	Hs
		463361 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		SHC1_HUMAN (378-616): 1.62e-51: 191: 23.01
+	Hs
		463392 LYN_HUMAN (8-357): 1.64e-64: 215: 15.78		KSYK_HUMAN (526-678): 1.12e-21: 102: 19.36
+	Hs
		988040 SH2B3_HUMAN (64-359): 5.78e-64: 215: 67.11		GRB2_HUMAN (517-609): 4.57e-15: 77: 22.58