HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8649391
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 575
+	Mm
		1221258 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		SH2B2_MOUSE (1-573): 2.17e-130: 396: 30.39
+	Hs
		154425 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SH2B2_HUMAN (25-573): 2.29e-117: 363: 31.30
+	Hs
		913636 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		VAV2_HUMAN (217-544): 4.28e-56: 204: 11.77
+	Mm
		1221220 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		VAV2_MOUSE (217-544): 4.99e-55: 201: 12.64
+	Hs
		584510 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		VAV_HUMAN (192-573): 3.19e-49: 184: 11.77
+	Hs
		557205 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SRC_HUMAN (204-553): 3.3e-47: 175: 13.17
+	Mm
		699355 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		VAV_MOUSE (192-573): 4.31e-44: 169: 11.00
+	Hs
		987513 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		GRB2_HUMAN (307-547): 3.38e-46: 163: 12.86
+	Hs
		855847 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CRKL_HUMAN (364-541): 1.25e-41: 154: 22.35
+	Rn
		988075 GRB2_RAT (1-217): 1.28e-70: 216: 100.00		SHC1_RAT (248-462): 3.22e-40: 154: 21.85
+	Hs
		593961 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		NCK1_HUMAN (286-446): 2.62e-38: 147: 18.39
+	Hs
		834167 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CSK_HUMAN (354-444): 2.07e-32: 131: 29.67
+	Hs
		987542 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SHC2_HUMAN (290-469): 3.8e-31: 129: 24.47
+	Mm
		1022218 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		SHC1_MOUSE (308-453): 3.06e-30: 126: 26.71
+	Hs
		711296 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		849135 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		KSYK_HUMAN (363-573): 1.76e-25: 112: 15.57
+	Mm
		1221223 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		PLCG1_MOUSE (348-556): 4.58e-20: 97: 17.86
+	Rn
		531972 GRB2_RAT (1-217): 1.28e-70: 216: 100.00		PLCG1_RAT (348-539): 3.1e-20: 97.4: 17.39
+	Hs
		619022 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PLCG1_HUMAN (348-575): 7.84e-20: 96.2: 14.96
+	Hs
		136362 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		P85B_HUMAN (329-463): 1.65e-18: 91.3: 18.38