Protein: SH2B3
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)

Gene: SH2B3
Organism: Homo sapiens
Interactions: 22
UniProt ID: Q9UQQ2

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005173 - stem cell factor receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532108

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.799

High

364047

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.778

High

411121

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

641706

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

472152

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

1145795

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1224936

TENS2
Tensin-2

1

17

High-throughput

0.621

High

253391

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

440246

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.618

High

619138

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

17

Small-scale

0.618

High

988040

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1104537

ILK
Scaffold protein ILK

1

20

Small-scale

0.618

High

972148

1433E
14-3-3 protein epsilon

2

7

High-throughput

0.571

High

637793

FLNA
Filamin-A

1

20

Small-scale

0.552

High

1462771

T22D4
TSC22 domain family protein 4

2

8

High-throughput

0.549

High

990883

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1136959

ABRX2
BRISC complex subunit Abraxas 2

1

3

Small-scale

0.479

High

691550

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

730366

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

1351544

HAVR2
Hepatitis A virus cellular receptor 2

1

4

Small-scale

0.445

High

1258621

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

1326755

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025