HitPredict

Interactor 1: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Interactor 2: RASF5 (Q8WWW0)
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
Gene: RASSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.80	0.662

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, RA~Ras
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 184 Hs			1 418
+	Mm
		1125491 RAP1B_MOUSE (1-184): 3.62e-74: 222: 100.00		RASF5_MOUSE (3-418): 0: 574: 85.10
+	Hs
		919655 RAP1A_HUMAN (1-184): 2.59e-69: 210: 95.11		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		897989 RAP2B_HUMAN (1-184): 1.46e-65: 200: 61.41		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		486042 RAP2A_HUMAN (1-166): 6.9e-61: 188: 65.66		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Mm
		1125490 RASH_MOUSE (1-167): 1.22e-55: 175: 57.49		RASF5_MOUSE (3-418): 0: 574: 85.10
+	Hs
		349532 RASH_HUMAN (1-167): 1.22e-55: 175: 57.49		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		350400 RASK_HUMAN (1-167): 6.26e-55: 174: 57.49		RASF5_HUMAN (1-418): 0: 574: 100.00
+	Hs
		349676 RASH_HUMAN (1-167): 1.22e-55: 175: 57.49		RASF1_HUMAN (87-410): 5.15e-145: 418: 45.10
+	Hs
		349196 RASH_HUMAN (1-167): 1.22e-55: 175: 57.49		RASF2_HUMAN (223-418): 2.59e-56: 190: 26.96
+	Hs
		349983 RASK_HUMAN (1-167): 6.26e-55: 174: 57.49		RASF2_HUMAN (223-418): 2.59e-56: 190: 26.96