HitPredict

Interactor 1: FXR2 (P51116)
RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2)
Gene: FXR2

Interactor 2: KCC2B (Q13554)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: CAMK2B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity GO:0043005 - neuron projection
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 666
+	Hs
		899882 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2B_HUMAN (1-666): 0: 723: 100.00
+	Hs
		900312 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2G_HUMAN (376-666): 6.67e-66: 228: 48.45
+	Hs
		900313 FXR2_HUMAN (1-673): 0: 1004: 100.00		KCC2D_HUMAN (503-666): 2.03e-63: 220: 69.51
+	Mm
		704217 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2B_MOUSE (436-666): 1e-69: 238: 60.94
+	Mm
		548950 FXR1_MOUSE (14-673): 0: 981: 62.83		KCC2A_MOUSE (493-663): 2.2e-59: 208: 61.40
+	Hs
		899883 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2G_HUMAN (376-666): 6.67e-66: 228: 48.45
+	Hs
		900231 FXR1_HUMAN (14-673): 0: 798: 51.34		KCC2A_HUMAN (493-663): 1.22e-59: 209: 61.40
+	Hs
		1056708 FMR1_HUMAN (310-475): 6.14e-45: 172: 41.42		KCC2B_HUMAN (1-666): 0: 723: 100.00
+	Mm
		704229 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2B_MOUSE (436-666): 1e-69: 238: 60.94
+	Mm
		1297178 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2G_MOUSE (428-666): 8.41e-69: 235: 57.74
+	Mm
		1244503 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2D_MOUSE (503-666): 2.03e-63: 220: 69.51
+	Mm
		548966 Q8BPK8_MOUSE (14-344): 0: 621: 71.90		KCC2A_MOUSE (493-663): 2.2e-59: 208: 61.40
+	Hs
		168676 FMR1_HUMAN (310-475): 6.14e-45: 172: 41.42		CSKP_HUMAN (10-308): 1.66e-81: 278: 46.73
+	Mm
		704207 FMR1_MOUSE (229-475): 4.62e-46: 174: 34.20		KCC2B_MOUSE (436-666): 1e-69: 238: 60.94
+	Mm
		777991 FMR1_MOUSE (229-475): 4.62e-46: 174: 34.20		KCC2G_MOUSE (428-666): 8.41e-69: 235: 57.74
+	Mm
		777929 FMR1_MOUSE (229-475): 4.62e-46: 174: 34.20		KCC2D_MOUSE (503-666): 2.03e-63: 220: 69.51
+	Mm
		548936 FMR1_MOUSE (229-475): 4.62e-46: 174: 34.20		KCC2A_MOUSE (493-663): 2.2e-59: 208: 61.40
+	Hs
		1057055 FMR1_HUMAN (310-475): 6.14e-45: 172: 41.42		KCC2A_HUMAN (493-663): 1.22e-59: 209: 61.40