Protein: KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)

Gene: KCC2A, Camk2a
Organism: Mus musculus
Interactions: 61
UniProt ID: P11798

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

548947

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

3

11

High-throughput

0.847

High

548932

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

2

16

Small-scale

0.757

High

548944

NMDE2
Glutamate receptor ionotropic, NMDA 2B

8

16

Small-scale

0.737

High

548943

RGS14
Regulator of G-protein signaling 14

1

4

High-throughput

0.724

High

60069

KALRN
Kalirin

1

8

High-throughput

0.691

High

312814

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.691

High

548942

TNIK
Traf2 and NCK-interacting protein kinase

1

8

High-throughput

0.691

High

548946

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

8

High-throughput

0.691

High

548962

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

14

High-throughput

0.691

High

548958

NEB2
Neurabin-2

4

20

Small-scale

0.680

High

104451

SYGP1
Ras/Rap GTPase-activating protein SynGAP

3

11

High-throughput

0.667

High

548952

DLG4
Disks large homolog 4

3

15

High-throughput

0.667

High

548951

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

Small-scale

0.665

High

548973

ACTN2
Alpha-actinin-2

1

6

Small-scale

0.648

High

548935

NMDZ1
Glutamate receptor ionotropic, NMDA 1

3

16

Small-scale

0.633

High

236879

ACK1
Activated CDC42 kinase 1

1

11

Small-scale

0.618

High

548931

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

3

High-throughput

0.618

High

548938

CDK5
Cyclin-dependent kinase 5

1

8

Small-scale

0.575

High

548934

ACM4
Muscarinic acetylcholine receptor M4

1

3

Small-scale

0.553

High

548948

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

5

High-throughput

0.536

High

548950

FXR1
RNA-binding protein FXR1

1

18

High-throughput

0.536

High

548960

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.536

High

548971

DLGP1
Disks large-associated protein 1

1

9

High-throughput

0.536

High

548972

TSC1
Hamartin

1

5

High-throughput

0.536

High

548941

IRF3
Interferon regulatory factor 3

1

0

Small-scale

0.530

High

548956

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

3

High-throughput

0.528

High

548978

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.528

High

548980

HOME1
Homer protein homolog 1

1

0

High-throughput

0.513

High

548964

RHG32
Rho GTPase-activating protein 32

1

7

Small-scale

0.501

High

548933

NCKP1
Nck-associated protein 1

1

1

High-throughput

0.489

High

548959

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

5

High-throughput

0.489

High

548961

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.489

High

548963

MYOME
Myomegalin

1

1

High-throughput

0.489

High

548968

PEX5R
PEX5-related protein

1

7

High-throughput

0.489

High

266667

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

Small-scale

0.480

High

97347

PRRT2
Proline-rich transmembrane protein 2

1

2

High-throughput

0.479

High

204983

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

313169

SYN1
Synapsin-1

1

2

Small-scale

0.479

High

548939

1433Z
14-3-3 protein zeta/delta

1

19

High-throughput

0.479

High

548949

PPP5
Serine/threonine-protein phosphatase 5

1

13

High-throughput

0.479

High

548967

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.458

High

548955

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

6

High-throughput

0.457

High

548969

ABI1
Abl interactor 1

1

7

High-throughput

0.457

High

548974

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

11

High-throughput

0.457

High

204714

CAN1
Calpain-1 catalytic subunit

1

11

Small-scale

0.445

High

548936

FMR1
Fragile X messenger ribonucleoprotein 1

1

18

High-throughput

0.445

High

548975

SRCN1
SRC kinase signaling inhibitor 1

1

4

High-throughput

0.445

High

108410

G3X9H5
Huntingtin

1

4

High-throughput

0.437

High

548945

TRI72
Tripartite motif-containing protein 72

1

4

Small-scale

0.437

High

548953

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

5

Small-scale

0.437

High

548954

INADL
InaD-like protein

1

16

Small-scale

0.437

High

548965

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

4

High-throughput

0.437

High

548966

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

18

High-throughput

0.437

High

548976

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.437

High

548979

MECP2
Methyl-CpG-binding protein 2

1

5

Small-scale

0.437

High

236365

O54737
BCA protein

1

2

High-throughput

0.417

High

548940

IMB1
Importin subunit beta-1

1

3

High-throughput

0.417

High

548970

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

2

High-throughput

0.417

High

548977

PDC6I
Programmed cell death 6-interacting protein

1

2

High-throughput

0.417

High

548937

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

High-throughput

0.238

Low

548957

GPBP1
Vasculin

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025