HitPredict

Interactor 1: RND3 (P61587)
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Gene: RND3

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.566

Property	Details
Experiments	23622247
Identification Methods	x-ray crystallography, isothermal titration calorimetry, surface plasmon resonance, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0019901 - protein kinase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 244 Hs			1 245
+	Hs
		893865 CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		925173 RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		683240 RND3_HUMAN (1-244): 1.15e-81: 246: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		892309 RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		892304 RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646769 RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683235 RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		436240 RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Mm
		935511 RHOC_MOUSE (22-213): 2.02e-92: 271: 49.48		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07
+	Hs
		904423 RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		564472 RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		564469 RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		893862 CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		893927 CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		904428 RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		683929 RND3_HUMAN (1-244): 1.15e-81: 246: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		545303 RAC2_HUMAN (24-211): 1.42e-76: 231: 39.89		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		900349 RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		892302 RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59