Protein: VPS21
Vacuolar protein sorting-associated protein 21 (GTP-binding protein YPT51) (Vacuolar protein-targeting protein 12)

Gene: VPS21
Organism: Saccharomyces cerevisiae S288C
Interactions: 87
UniProt ID: P36017

Gene Ontology (top 5):
GO:0000011 - vacuole inheritance
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

779610

GDI1
Rab GDP-dissociation inhibitor

8

20

Small-scale

0.969

High

746358

RAEP
Rab proteins geranylgeranyltransferase component A

4

20

High-throughput

0.904

High

743658

PEP7
Vacuolar segregation protein PEP7

4

20

Small-scale

0.889

High

779628

VPS9
Vacuolar protein sorting-associated protein 9

3

20

Small-scale

0.870

High

779619

GYP3
GTPase-activating protein GYP3

3

20

Small-scale

0.863

High

779601

YPT53
GTP-binding protein YPT53

2

19

Small-scale

0.808

High

779600

YPT52
GTP-binding protein YPT52

2

17

Small-scale

0.793

High

779599

VPS21
Vacuolar protein sorting-associated protein 21

2

18

Small-scale

0.776

High

779608

VPS8
Vacuolar protein sorting-associated protein 8

7

6

Small-scale

0.741

High

779632

MUK1
Protein MUK1

2

0

Small-scale

0.737

High

661744

VPS3
Vacuolar protein sorting-associated protein 3

5

1

Small-scale

0.710

High

448586

RHO2
GTP-binding protein RHO2

1

20

High-throughput

0.691

High

656419

KC11
Casein kinase I homolog 1

1

8

High-throughput

0.691

High

779603

YPT10
GTP-binding protein YPT10

1

19

Small-scale

0.680

High

779641

GYP1
GTPase-activating protein GYP1

1

20

Small-scale

0.647

High

748726

YPT7
Ypt/Rab-type GTPase YPT7

1

20

Small-scale

0.621

High

779645

YPT6
GTP-binding protein YPT6

1

19

Small-scale

0.621

High

660320

STE11
Serine/threonine-protein kinase STE11

1

4

High-throughput

0.618

High

544436

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.618

High

646653

VPS15
Serine/threonine-protein kinase VPS15

1

12

High-throughput

0.618

High

649812

VPS34
Phosphatidylinositol 3-kinase VPS34

1

20

High-throughput

0.618

High

743378

TOR2
Serine/threonine-protein kinase TOR2

1

12

Small-scale

0.618

High

579187

HSC82
ATP-dependent molecular chaperone HSC82

2

14

High-throughput

0.594

High

779604

ATG8
Autophagy-related protein 8

2

8

High-throughput

0.584

High

692331

KCC1
Calcium/calmodulin-dependent protein kinase I

1

2

High-throughput

0.579

High

779606

RCK1
Serine/threonine-protein kinase RCK1

1

5

High-throughput

0.579

High

779634

TDA1
Serine/threonine-protein kinase TDA1

1

7

High-throughput

0.579

High

506445

U5072
UPF0507 protein YML002W

1

1

Small-scale

0.555

High

779625

YIF1
Protein transport protein YIF1

2

7

Small-scale

0.543

High

748211

VAM7
Vacuolar morphogenesis protein 7

1

8

Small-scale

0.541

High

779620

HSV2
SVP1-like protein 2

1

7

High-throughput

0.541

High

779621

YIP1
Protein transport protein YIP1

2

11

Small-scale

0.533

High

779617

JJJ2
J protein JJJ2

1

5

High-throughput

0.514

High

628316

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

9

Small-scale

0.501

High

779629

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

9

Small-scale

0.501

High

358998

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.500

High

359457

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.500

High

367734

ENO1
Enolase 1

1

1

High-throughput

0.500

High

454097

DHE4
NADP-specific glutamate dehydrogenase 1

1

2

High-throughput

0.500

High

460328

SYV
Valine--tRNA ligase, mitochondrial

1

1

High-throughput

0.500

High

538335

PYC1
Pyruvate carboxylase 1

1

3

High-throughput

0.500

High

622351

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.500

High

709692

BMH1
Protein BMH1

1

3

High-throughput

0.500

High

760235

BMH2
Protein BMH2

1

3

High-throughput

0.500

High

760571

TSA1
Peroxiredoxin TSA1

1

4

High-throughput

0.500

High

779602

SSDH
Succinate-semialdehyde dehydrogenase [NADP(+)]

1

5

High-throughput

0.494

High

779627

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.493

High

556600

PEP5
E3 ubiquitin-protein ligase PEP5

1

4

Small-scale

0.481

High

432317

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439310

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

779609

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

582442

SEC23
Protein transport protein SEC23

1

7

High-throughput

0.479

High

726929

HS104
Heat shock protein 104

1

5

High-throughput

0.479

High

752111

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.479

High

779616

ATG27
Autophagy-related protein 27

1

2

High-throughput

0.479

High

779626

ATG2
Autophagy-related protein 2

1

4

High-throughput

0.479

High

779633

BECN1
Vacuolar protein sorting-associated protein 30

1

2

High-throughput

0.479

High

779642

ATG9
Autophagy-related protein 9

1

3

High-throughput

0.479

High

779643

ATG11
Autophagy-related protein 11

1

1

High-throughput

0.479

High

779624

PRA1
Prenylated Rab acceptor 1

1

20

Small-scale

0.464

High

750824

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.457

High

523583

HSP71
Heat shock protein SSA1

1

11

High-throughput

0.445

High

526384

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

779612

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

779635

GRH1
GRASP65 homolog protein 1

1

6

High-throughput

0.445

High

779631

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

779640

VAM6
Vacuolar morphogenesis protein 6

1

20

Small-scale

0.439

High

744600

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.438

High

705157

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

706761

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

779605

ATG14
Autophagy-related protein 14

1

1

High-throughput

0.437

High

779613

SEC24
Protein transport protein SEC24

1

7

High-throughput

0.437

High

779637

SEC13
Protein transport protein SEC13

1

10

High-throughput

0.437

High

779639

ATG23
Autophagy-related protein 23

1

2

High-throughput

0.437

High

779622

YIP5
Protein YIP5

1

3

Small-scale

0.417

High

779615

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

779630

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.279

Low

779607

ARO9
Aromatic amino acid aminotransferase 2

1

0

High-throughput

0.261

Low

779614

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.261

Low

776435

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

Small-scale

0.251

Low

779611

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

Small-scale

0.251

Low

779618

SNAPN
Biogenesis of lysosome-related organelles complex 1 subunit SNN1

1

0

Small-scale

0.251

Low

779623

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

Small-scale

0.251

Low

779638

BL1S4
Biogenesis of lysosome-related organelles complex 1 subunit CNL1

1

0

Small-scale

0.251

Low

779644

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.238

Low

779636

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025