HitPredict

Interactor 1: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Interactor 2: STX19 (Q8N4C7)
Syntaxin-19
Gene: STX19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	25416956, 25910212, 32296183, 26186194, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Sec1~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0048787 - presynaptic active zone membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 594 Hs			1 294
+	Mm
		139528 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1A_MOUSE (8-288): 1.56e-68: 216: 28.72
+	Bt
		699167 STXB1_BOVIN (1-594): 0: 680: 100.00		STX1A_BOVIN (8-288): 8.67e-69: 216: 28.72
+	Rn
		699173 STXB1_RAT (1-594): 0: 680: 100.00		STX1A_RAT (8-288): 2.27e-68: 215: 29.08
+	Hs
		901790 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1A_HUMAN (8-288): 8.61e-68: 214: 28.72
+	Mm
		139543 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1B_MOUSE (8-288): 3.71e-67: 212: 28.01
+	Rn
		898824 STXB1_RAT (1-594): 0: 680: 100.00		STX1B_RAT (8-288): 3.71e-67: 212: 28.01
+	Hs
		898829 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1B_HUMAN (8-288): 3.71e-67: 212: 28.01
+	Hs
		699253 STXB1_HUMAN (1-594): 0: 680: 100.00		STX2_HUMAN (24-288): 5.11e-65: 207: 26.32
+	Rn
		838509 STXB1_RAT (1-594): 0: 680: 100.00		STX2_RAT (29-283): 8.99e-62: 199: 27.34
+	Mm
		192851 STXB2_MOUSE (1-593): 0: 659: 62.80		STX1A_MOUSE (8-288): 1.56e-68: 216: 28.72
+	Hs
		269405 STXB1_HUMAN (1-594): 0: 680: 100.00		STX11_HUMAN (1-290): 1.64e-58: 190: 36.43
+	Hs
		901776 STXB1_HUMAN (1-594): 0: 680: 100.00		STX4_HUMAN (8-289): 1.34e-56: 186: 27.47
+	Hs
		699262 STXB2_HUMAN (1-593): 0: 658: 63.47		STX2_HUMAN (24-288): 5.11e-65: 207: 26.32
+	Mm
		139547 STXB1_MOUSE (1-594): 0: 680: 100.00		STX4_MOUSE (8-289): 8.44e-54: 178: 25.00
+	Rn
		901847 STXB1_RAT (1-594): 0: 680: 100.00		STX4_RAT (8-289): 4.76e-53: 176: 25.00
+	Hs
		901780 STXB1_HUMAN (1-594): 0: 680: 100.00		STX3_HUMAN (1-281): 1.76e-52: 175: 29.08
+	Rn
		901846 STXB1_RAT (1-594): 0: 680: 100.00		STX3_RAT (1-281): 1.79e-51: 172: 28.72
+	Hs
		269420 STXB2_HUMAN (1-593): 0: 658: 63.47		STX11_HUMAN (1-290): 1.64e-58: 190: 36.43
+	Mm
		936823 STXB2_MOUSE (1-593): 0: 659: 62.80		STX4_MOUSE (8-289): 8.44e-54: 178: 25.00
+	Mm
		1145332 STXB2_MOUSE (1-593): 0: 659: 62.80		STX3_MOUSE (1-281): 3.24e-51: 171: 28.72