HitPredict

Interactor 1: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Interactor 2: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21145461
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 342 Hs			1 745
+	Hs
		902909 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		902910 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		902908 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		1043016 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		997714 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1043376 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		997715 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		1041672 RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		997713 RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Hs
		302286 SC31A_HUMAN (23-342): 1.55e-55: 197: 17.56		CUL3_HUMAN (1-745): 0: 768: 26.38
+	Ce
		953927 LIN53_CAEEL (10-342): 2.97e-67: 218: 14.88		CUL2_CAEEL (2-745): 0: 720: 42.27
+	Ce
		953926 LIN53_CAEEL (10-342): 2.97e-67: 218: 14.88		CUL1_CAEEL (4-745): 0: 712: 30.76
+	Hs
		1043157 SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		1043509 SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	At
		186930 MSI1_ARATH (17-342): 3.99e-58: 195: 15.00		CUL4_ARATH (4-745): 0: 720: 26.60
+	Hs
		902987 DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00		CUL5_HUMAN (7-745): 0: 627: 26.69
+	Hs
		903206 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL1_HUMAN (6-745): 0: 775: 36.24
+	Hs
		903208 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL4A_HUMAN (4-745): 0: 773: 26.86
+	Hs
		903209 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL4B_HUMAN (4-745): 0: 771: 27.79
+	Hs
		903207 WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85		CUL3_HUMAN (1-745): 0: 768: 26.38