HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	38697112, 38943005
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 165
+	Hs
		905289 MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00		PPIE_HUMAN (2-163): 2.09e-88: 262: 67.28
+	Hs
		656079 MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00		PPIB_HUMAN (2-165): 9.5e-88: 257: 63.64
+	Hs
		216237 MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00		PPIH_HUMAN (2-164): 1.39e-84: 247: 53.85
+	Hs
		890423 MECP2_HUMAN (1-486): 5.18e-113: 344: 100.00		RBP2_HUMAN (3-164): 1.88e-73: 240: 66.67
+	Mm
		607854 MBD2_MOUSE (75-249): 2.82e-38: 146: 28.09		PPIA_MOUSE (1-164): 9.93e-90: 260: 96.34
+	Hs
		986598 TITIN_HUMAN (240-472): 1.29e-12: 72.8: 19.57		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		656156 NIPBL_HUMAN (72-455): 1.96e-09: 62.4: 14.06		PPIB_HUMAN (2-165): 9.5e-88: 257: 63.64