HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: KGP1 (Q13976)
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)
Gene: PRKG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 671
+	Dm
		820489 PRS4_DROME (4-396): 3.02e-138: 403: 45.04		AKT1_DROME (228-666): 6.63e-151: 452: 28.63
+	Hs
		681769 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		AKT1_HUMAN (243-666): 7.34e-152: 450: 29.66
+	Hs
		906937 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		KS6B2_HUMAN (333-665): 2.73e-140: 420: 38.17
+	Dm
		1181018 Q7KMQ0_DROME (81-392): 1.77e-115: 345: 55.45		AKT1_DROME (228-666): 6.63e-151: 452: 28.63
+	Hs
		730374 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		KS6B2_HUMAN (333-665): 2.73e-140: 420: 38.17
+	Dm
		186123 PRS8_DROME (8-123): 6.29e-11: 65.5: 7.76		AKT1_DROME (228-666): 6.63e-151: 452: 28.63
+	Dm
		1213440 Q9W414_DROME (8-101): 2.04e-10: 64: 10.64		AKT1_DROME (228-666): 6.63e-151: 452: 28.63
+	Sc
		409673 PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77		KAPC_YEAST (357-655): 3.65e-80: 261: 44.00