HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: RN146 (Q9NTX7)
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
Gene: RNF146

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 359
+	Hs
		919875 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		RN146_HUMAN (1-359): 0: 605: 100.00
+	Hs
		849458 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		RN146_HUMAN (1-359): 0: 605: 100.00
+	Hs
		895926 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		RN146_HUMAN (1-359): 0: 605: 100.00