HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ThiF~UQ_con, UAE_UbL~UQ_con
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 640
+	Hs
		1282360 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Hs
		607190 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607050 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607026 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607039 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		908500 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		ULA1_HUMAN (4-331): 5.33e-70: 238: 18.73
+	Hs
		607129 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607136 UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Sc
		549788 UBC4_YEAST (1-149): 7.24e-71: 212: 32.03		UBA1_YEAST (6-634): 3.33e-56: 207: 15.10
+	Hs
		607023 UBE2A_HUMAN (4-150): 8.87e-65: 197: 30.46		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607028 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		607047 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		919796 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA3_HUMAN (294-534): 1.16e-56: 200: 21.29
+	Hs
		607054 UBE2B_HUMAN (4-149): 8e-64: 195: 30.67		UBA1_HUMAN (6-634): 1.14e-60: 221: 13.71
+	Hs
		313128 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		MOCS3_HUMAN (7-177): 2.65e-60: 210: 29.65
+	Hs
		782203 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		UBA7_HUMAN (6-622): 7.06e-40: 159: 14.17
+	Hs
		48107 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UBA6_HUMAN (392-634): 9.94e-20: 95.9: 11.46
+	Hs
		48104 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UBA6_HUMAN (392-634): 9.94e-20: 95.9: 11.46
+	Sp
		293848 UBC4_SCHPO (7-149): 2.5e-70: 211: 29.25		UBA1_SCHPO (6-149): 4.52e-21: 100: 18.06
+	Hs
		48106 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		UBA6_HUMAN (392-634): 9.94e-20: 95.9: 11.46