Protein: DAPK1
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)

Gene: DAPK1
Organism: Homo sapiens
Interactions: 207
UniProt ID: P53355

Gene Ontology (top 5):
GO:0002357 - defense response to tumor cell
GO:0002834 - regulation of response to tumor cell
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862012

DAPK1
Death-associated protein kinase 1

5

18

Small-scale

0.941

High

862121

LIMA1
LIM domain and actin-binding protein 1

2

5

High-throughput

0.812

High

812967

CAZA2
F-actin-capping protein subunit alpha-2

2

5

High-throughput

0.811

High

813264

CAPZB
F-actin-capping protein subunit beta

2

4

High-throughput

0.811

High

672045

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

8

Small-scale

0.799

High

658865

MK01
Mitogen-activated protein kinase 1

1

14

Small-scale

0.774

High

862073

UNC5B
Netrin receptor UNC5B

2

8

Small-scale

0.757

High

862033

FADD
FAS-associated death domain protein

2

10

Small-scale

0.754

High

259715

PDCD6
Programmed cell death protein 6

1

18

Small-scale

0.740

High

647524

MK03
Mitogen-activated protein kinase 3

1

13

Small-scale

0.740

High

862142

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.724

High

862134

KLH20
Kelch-like protein 20

3

1

Small-scale

0.698

High

150542

ABLM1
Actin-binding LIM protein 1

1

2

High-throughput

0.692

High

266943

SRS10
Serine/arginine-rich splicing factor 10

1

4

High-throughput

0.692

High

313168

RPGF3
Rap guanine nucleotide exchange factor 3

1

8

High-throughput

0.692

High

337406

ABL1
Tyrosine-protein kinase ABL1

1

13

High-throughput

0.692

High

446550

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.692

High

507555

PIM1
Serine/threonine-protein kinase pim-1

1

19

High-throughput

0.692

High

549880

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

17

High-throughput

0.692

High

600539

EPHA1
Ephrin type-A receptor 1

1

8

High-throughput

0.692

High

796462

ZAP70
Tyrosine-protein kinase ZAP-70

1

19

High-throughput

0.692

High

816234

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

2

High-throughput

0.692

High

862023

TBB4B
Tubulin beta-4B chain

1

18

High-throughput

0.692

High

862076

FXL14
F-box/LRR-repeat protein 14

1

5

High-throughput

0.692

High

862091

SCYL1
N-terminal kinase-like protein

1

13

High-throughput

0.692

High

862105

SGK2
Serine/threonine-protein kinase Sgk2

1

8

High-throughput

0.692

High

862107

PAK6
Serine/threonine-protein kinase PAK 6

1

12

High-throughput

0.692

High

862116

PIM2
Serine/threonine-protein kinase pim-2

1

17

High-throughput

0.692

High

862125

BORG2
Cdc42 effector protein 3

1

2

High-throughput

0.692

High

521508

ACTN1
Alpha-actinin-1

1

20

High-throughput

0.691

High

571370

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.691

High

647851

MARK3
MAP/microtubule affinity-regulating kinase 3

1

11

High-throughput

0.691

High

857088

CAZA1
F-actin-capping protein subunit alpha-1

1

5

High-throughput

0.691

High

862016

ARP3
Actin-related protein 3

1

8

High-throughput

0.691

High

862017

ARP2
Actin-related protein 2

1

8

High-throughput

0.691

High

862022

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.691

High

862030

NEXN
Nexilin

1

13

High-throughput

0.691

High

862037

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.691

High

862039

SRC8
Src substrate cortactin

1

20

High-throughput

0.691

High

862065

MARK2
Serine/threonine-protein kinase MARK2

1

13

High-throughput

0.691

High

862115

MARK1
Serine/threonine-protein kinase MARK1

1

13

High-throughput

0.691

High

862048

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

6

Small-scale

0.665

High

862054

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

Small-scale

0.665

High

862113

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.656

High

159558

ML12B
Myosin regulatory light chain 12B

1

20

Small-scale

0.647

High

862046

Q2YDB1
RASGRP2 protein

1

7

High-throughput

0.647

High

862067

GRP2
RAS guanyl-releasing protein 2

1

5

High-throughput

0.647

High

862130

CHIP
E3 ubiquitin-protein ligase CHIP

2

14

High-throughput

0.629

High

214538

MYO1B
Unconventional myosin-Ib

2

20

High-throughput

0.628

High

297324

MYO1D
Unconventional myosin-Id

2

19

High-throughput

0.628

High

313783

SVIL
Supervillin

2

9

High-throughput

0.628

High

862031

TWF1
Twinfilin-1

2

5

High-throughput

0.628

High

862128

COR1C
Coronin-1C

2

6

High-throughput

0.628

High

862020

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

1

Small-scale

0.620

High

131819

KRIT1
Krev interaction trapped protein 1

1

19

Small-scale

0.618

High

306907

UNC5C
Netrin receptor UNC5C

1

6

Small-scale

0.618

High

349212

RASH
GTPase HRas

1

11

High-throughput

0.618

High

386364

P53
Cellular tumor antigen p53

1

7

Small-scale

0.618

High

431682

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

475511

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.618

High

584350

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.618

High

672390

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

11

Small-scale

0.618

High

862018

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.618

High

862063

UNC5A
Netrin receptor UNC5A

1

11

Small-scale

0.618

High

862070

MIB1
E3 ubiquitin-protein ligase MIB1

1

16

Small-scale

0.618

High

862139

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

10

High-throughput

0.618

High

835031

TSC2
Tuberin

2

4

Small-scale

0.601

High

862021

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

5

Small-scale

0.595

High

862041

BECN1
Beclin-1

1

0

Small-scale

0.593

High

575345

EGR1
Early growth response protein 1

1

0

High-throughput

0.586

High

537851

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.586

High

862028

ANK2
Ankyrin-2

1

17

High-throughput

0.575

High

323655

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.574

High

862096

ERP44
Endoplasmic reticulum resident protein 44

2

13

High-throughput

0.574

High

862112

TMOD3
Tropomodulin-3

2

4

High-throughput

0.574

High

862043

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.537

High

579325

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

20

High-throughput

0.536

High

722580

T2FA
General transcription factor IIF subunit 1

1

4

High-throughput

0.536

High

777830

RFC5
Replication factor C subunit 5

1

2

High-throughput

0.536

High

862034

CBLB
E3 ubiquitin-protein ligase CBL-B

1

3

High-throughput

0.536

High

862035

PWP1
Periodic tryptophan protein 1 homolog

1

6

High-throughput

0.536

High

862040

CAPR1
Caprin-1

1

6

High-throughput

0.536

High

862042

STAR3
StAR-related lipid transfer protein 3

1

1

High-throughput

0.536

High

862075

CNTRB
Centrobin

1

9

High-throughput

0.536

High

862078

ARRD1
Arrestin domain-containing protein 1

1

3

High-throughput

0.536

High

862080

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.536

High

862083

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.536

High

862093

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

2

High-throughput

0.536

High

862101

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.536

High

862106

SH22A
SH2 domain-containing protein 2A

1

17

High-throughput

0.536

High

862120

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

4

High-throughput

0.536

High

862122

ZMYM5
Zinc finger MYM-type protein 5

1

1

High-throughput

0.536

High

862124

FBW1B
F-box/WD repeat-containing protein 11

1

12

High-throughput

0.536

High

862132

BAIP2
BAR/IMD domain-containing adapter protein 2

1

13

High-throughput

0.536

High

862140

SNX9
Sorting nexin-9

1

3

High-throughput

0.536

High

117643

MYO1C
Unconventional myosin-Ic

1

19

High-throughput

0.536

High

164586

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

20

High-throughput

0.536

High

168757

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

3

High-throughput

0.536

High

181306

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

High-throughput

0.536

High

211541

ACTN4
Alpha-actinin-4

1

19

High-throughput

0.536

High

241157

TOM1
Target of Myb1 membrane trafficking protein

1

3

High-throughput

0.536

High

254064

WDR1
WD repeat-containing protein 1

1

2

High-throughput

0.536

High

413867

GELS
Gelsolin

1

9

High-throughput

0.536

High

418921

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.536

High

531091

EF2
Elongation factor 2

1

1

High-throughput

0.536

High

725931

ADDA
Alpha-adducin

1

9

High-throughput

0.536

High

726022

ADDB
Beta-adducin

1

8

High-throughput

0.536

High

862015

DEST
Destrin

1

5

High-throughput

0.536

High

862024

CNTP1
Contactin-associated protein 1

1

6

High-throughput

0.536

High

862027

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.536

High

862032

FLII
Protein flightless-1 homolog

1

11

High-throughput

0.536

High

862044

DREB
Drebrin

1

11

High-throughput

0.536

High

862047

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

2

High-throughput

0.536

High

862084

TSC1
Hamartin

1

16

Small-scale

0.536

High

862085

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

3

High-throughput

0.536

High

862086

COR2A
Coronin-2A

1

7

High-throughput

0.536

High

862095

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

High-throughput

0.536

High

862119

ADDG
Gamma-adducin

1

8

High-throughput

0.536

High

862127

MYO5B
Unconventional myosin-Vb

1

9

High-throughput

0.536

High

862129

MYO6
Unconventional myosin-VI

1

15

High-throughput

0.536

High

862131

COR2B
Coronin-2B

1

6

High-throughput

0.536

High

862133

COF2
Cofilin-2

1

5

High-throughput

0.536

High

862135

SGT1
Protein SGT1 homolog

1

14

High-throughput

0.536

High

862143

SCIN
Scinderin

1

9

High-throughput

0.536

High

862057

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

Small-scale

0.528

High

862036

CUL3
Cullin-3

1

13

Small-scale

0.515

High

862137

HYOU1
Hypoxia up-regulated protein 1

1

19

High-throughput

0.515

High

203285

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.513

High

306575

SCEL
Sciellin

1

0

High-throughput

0.513

High

311410

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.513

High

329147

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.513

High

819528

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

862013

T2R60
Taste receptor type 2 member 60

1

0

High-throughput

0.513

High

862019

RS32
Small ribosomal subunit protein eS32

1

0

High-throughput

0.513

High

862025

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

862038

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.513

High

862045

TPD53
Tumor protein D53

1

0

High-throughput

0.513

High

862049

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.513

High

862055

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.513

High

862066

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.513

High

862069

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

862072

HYCC2
Hyccin 2

1

0

High-throughput

0.513

High

862079

NECA1
N-terminal EF-hand calcium-binding protein 1

1

0

High-throughput

0.513

High

862094

DUX3
Putative double homeobox protein 3

1

0

High-throughput

0.513

High

862100

VN1R1
Vomeronasal type-1 receptor 1

1

0

High-throughput

0.513

High

862104

ZMAT4
Zinc finger matrin-type protein 4

1

0

High-throughput

0.513

High

862109

C42S1
CDC42 small effector protein 1

1

0

High-throughput

0.513

High

862111

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.513

High

862118

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.513

High

862136

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.513

High

862141

SNURF
SNRPN upstream reading frame protein

1

0

High-throughput

0.513

High

168902

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

169055

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.513

High

862014

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

862123

SH3L2
SH3 domain-binding glutamic acid-rich-like protein 2

1

0

High-throughput

0.513

High

66338

A8K2B9
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.501

High

483237

TPC2A
Trafficking protein particle complex subunit 2

1

2

High-throughput

0.501

High

483296

TPC2B
Trafficking protein particle complex subunit 2B

1

2

High-throughput

0.501

High

627219

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.501

High

862077

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.501

High

862082

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.501

High

862088

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

534292

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

5

High-throughput

0.489

High

862029

SCRN3
Secernin-3

1

1

High-throughput

0.489

High

862051

LARGN
Protein Largen

1

1

High-throughput

0.489

High

862061

TTC27
Tetratricopeptide repeat protein 27

1

13

High-throughput

0.489

High

862071

DEN1C
DENN domain-containing protein 1C

1

6

High-throughput

0.489

High

862102

CI037
Uncharacterized protein ARRDC1-AS1

1

1

High-throughput

0.489

High

862103

RPAP3
RNA polymerase II-associated protein 3

1

18

High-throughput

0.489

High

862110

TB22B
TBC1 domain family member 22B

1

2

High-throughput

0.489

High

657472

TMOD1
Tropomodulin-1

1

4

High-throughput

0.489

High

862056

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

13

High-throughput

0.489

High

862092

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.489

High

862098

CP250
Centrosome-associated protein CEP250

1

7

High-throughput

0.489

High

862114

TMOD2
Tropomodulin-2

1

4

High-throughput

0.489

High

862126

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.489

High

377204

GCR
Glucocorticoid receptor

1

7

Small-scale

0.481

High

473898

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.480

High

455254

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

527364

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

646746

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

839921

F10A1
Hsc70-interacting protein

1

20

Small-scale

0.479

High

862052

DCAF6
DDB1- and CUL4-associated factor 6

1

11

High-throughput

0.479

High

862138

TTLL3
Tubulin monoglycylase TTLL3

1

2

High-throughput

0.479

High

329529

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

862108

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

310139

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.458

High

862090

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

862087

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.445

High

862053

PRC2B
Protein PRRC2B

1

15

High-throughput

0.439

High

862144

NS1BP
Influenza virus NS1A-binding protein

1

3

Small-scale

0.437

High

862026

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.408

High

526650

GILT
Gamma-interferon-inducible lysosomal thiol reductase

5

0

High-throughput

0.376

High

862050

ORML2
ORM1-like protein 2

1

0

High-throughput

0.279

Low

862059

JHY
Jhy protein homolog

1

0

High-throughput

0.279

Low

862060

DUS1L
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

1

0

High-throughput

0.279

Low

862062

GAK1B
Golgi-associated kinase 1B

1

0

High-throughput

0.279

Low

862064

CC149
Coiled-coil domain-containing protein 149

1

0

High-throughput

0.279

Low

862068

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

862074

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

1

0

High-throughput

0.279

Low

862081

MFI
Protein MFI

1

0

High-throughput

0.279

Low

862089

PP14A
Protein phosphatase 1 regulatory subunit 14A

1

0

High-throughput

0.279

Low

862097

LMF2
Lipase maturation factor 2

1

0

High-throughput

0.279

Low

862099

SPR2G
Small proline-rich protein 2G

1

0

High-throughput

0.279

Low

862117

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

862058

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024