HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	30773093, 36931259, 36950384, 15369779
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 763
+	Mm
		910255 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DYR1A_MOUSE (1-763): 0: 610: 99.21
+	Hs
		910197 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYR1B_HUMAN (57-600): 2.33e-137: 421: 68.13
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (105-758): 2.37e-123: 388: 17.87
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (105-761): 1.81e-121: 383: 17.49
+	Hs
		909877 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53
+	Hs
		910066 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYRK4_HUMAN (132-590): 2.67e-118: 367: 35.78
+	Hs
		681770 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12
+	Hv
		664586 1433A_HORVU (4-255): 3.05e-145: 408: 73.23		Q70YJ0_HORVU (70-673): 3.57e-119: 372: 21.04
+	Sc
		539240 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	Sc
		539232 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	Hs
		909828 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HIPK4_HUMAN (157-478): 1.65e-53: 197: 38.30
+	At
		847169 14332_ARATH (4-255): 1.05e-147: 414: 74.41		AFC1_ARATH (141-485): 6.57e-53: 192: 32.17
+	Zm
		27099 B6SRI4_MAIZE (4-255): 1.29e-145: 409: 70.47		A0A1D6JDK3_MAIZE (136-478): 9.83e-51: 193: 33.58