HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 601
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (219-542): 1.22e-134: 396: 27.80
+	Hs
		909458 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		909547 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK13_HUMAN (3-598): 8.85e-117: 381: 19.87
+	Hs
		910066 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYRK4_HUMAN (119-595): 5.24e-124: 377: 44.24
+	Hs
		909539 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Mm
		910255 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DYR1A_MOUSE (211-537): 3.58e-117: 367: 42.52
+	Hs
		910197 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYR1B_HUMAN (149-537): 1.88e-118: 366: 39.11
+	At
		847169 14332_ARATH (4-255): 1.05e-147: 414: 74.41		AFC1_ARATH (176-537): 5.75e-111: 342: 31.97
+	Sc
		539240 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		YAK1_YEAST (117-573): 7.71e-111: 352: 32.27
+	Sc
		539232 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		YAK1_YEAST (117-573): 7.71e-111: 352: 32.27
+	Sc
		565487 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		PHO85_YEAST (220-543): 3.63e-117: 352: 26.35
+	Zm
		27099 B6SRI4_MAIZE (4-255): 1.29e-145: 409: 70.47		A0A1D6JDK3_MAIZE (161-535): 2.37e-55: 203: 33.63