HitPredict

Interactor 1: IMA (P52295)
Importin subunit alpha (Karyopherin subunit alpha) (Pendulin)
Gene: Pen

Interactor 2: Q9V455 (Q9V455)
Importin subunit alpha
Gene: Kap-alpha3

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Arm, Arm~Arm_3, Arm~IBB, Arm_3~IBB
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006607 - NLS-bearing protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0061608 - nuclear import signal receptor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 522 Dm			1 514
+	Hs
		138588 IMA3_HUMAN (6-522): 1.84e-144: 427: 45.84		IMA4_HUMAN (5-514): 6.23e-157: 458: 67.38
+	Mm
		911176 IMA1_MOUSE (8-522): 2.98e-137: 409: 48.85		IMA1_MOUSE (2-514): 3.15e-145: 429: 48.00
+	Hs
		179011 IMA7_HUMAN (2-521): 4.05e-134: 401: 46.53		IMA6_HUMAN (4-514): 1.15e-139: 415: 44.07
+	Sc
		1039014 IMA1_YEAST (7-522): 5.52e-132: 396: 40.34		IMA1_YEAST (5-514): 2.67e-141: 419: 42.59
+	Sp
		313951 IMA2_SCHPO (1-522): 5.92e-132: 395: 40.52		IMA2_SCHPO (2-514): 5.19e-141: 418: 42.78
+	Hs
		253602 IMA7_HUMAN (2-521): 4.05e-134: 401: 46.53		IMA5_HUMAN (4-514): 9.79e-138: 410: 44.65
+	Hs
		179036 IMA6_HUMAN (2-521): 3.76e-130: 391: 45.71		IMA5_HUMAN (4-514): 9.79e-138: 410: 44.65
+	Sp
		152691 IMA2_SCHPO (1-522): 5.92e-132: 395: 40.52		IMA1_SCHPO (5-514): 7.95e-134: 400: 43.37