HitPredict

Interactor 1: E3CTP7 (E3CTP7)
Epidermal growth factor receptor pathway substrate clone 15, isoform D (MIP26607p)
Gene: Eps-15

Interactor 2: AP2A (P91926)
AP-2 complex subunit alpha (Alpha-adaptin)
Gene: AP-2alpha

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17620409, 16709407
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0048488 - synaptic vesicle endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 792 Dm			1 940
+	Hs
		302157 ITSN1_HUMAN (112-781): 2.93e-53: 202: 18.24		AP2A2_HUMAN (1-940): 0: 829: 69.18
+	Hs
		321552 ITSN1_HUMAN (112-781): 2.93e-53: 202: 18.24		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Rn
		88768 ITSN1_RAT (112-767): 2.9e-51: 196: 18.51		D3ZUY8_RAT (1-940): 0: 817: 67.01
+	Rn
		1126749 Q5JC29_RAT (5-415): 1.44e-37: 152: 16.22		Q66HM2_RAT (1-940): 0: 835: 69.46
+	Hs
		302112 EPS15_HUMAN (5-417): 2.05e-38: 155: 15.90		AP2A2_HUMAN (1-940): 0: 829: 69.18
+	Mm
		567515 EPS15_MOUSE (5-415): 3.49e-35: 145: 15.98		AP2A2_MOUSE (1-940): 0: 837: 69.67
+	Hs
		302221 EP15R_HUMAN (6-425): 2.8e-36: 149: 15.11		AP2A2_HUMAN (1-940): 0: 829: 69.18
+	Hs
		321504 EPS15_HUMAN (5-417): 2.05e-38: 155: 15.90		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Rn
		88764 Q5JC29_RAT (5-415): 1.44e-37: 152: 16.22		D3ZUY8_RAT (1-940): 0: 817: 67.01
+	Hs
		321661 EP15R_HUMAN (6-425): 2.8e-36: 149: 15.11		AP2A1_HUMAN (1-940): 0: 815: 65.48
+	Ce
		1094946 Q9U2T9_CAEEL (6-563): 2.36e-35: 146: 16.01		Q22601_CAEEL (1-940): 0: 773: 65.29
+	Hs
		925876 ITSN1_HUMAN (112-781): 2.93e-53: 202: 18.24		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Rn
		923861 ITSN1_RAT (112-767): 2.9e-51: 196: 18.51		AP2B1_RAT (33-935): 0: 669: 16.31
+	Hs
		1014017 ITSN1_HUMAN (112-781): 2.93e-53: 202: 18.24		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Hs
		787890 EPS15_HUMAN (5-417): 2.05e-38: 155: 15.90		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Rn
		923853 Q5JC29_RAT (5-415): 1.44e-37: 152: 16.22		AP2B1_RAT (33-935): 0: 669: 16.31
+	Hs
		926038 EP15R_HUMAN (6-425): 2.8e-36: 149: 15.11		AP2B1_HUMAN (33-935): 0: 669: 16.31
+	Hs
		787903 EPS15_HUMAN (5-417): 2.05e-38: 155: 15.90		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Hs
		1014098 EP15R_HUMAN (6-425): 2.8e-36: 149: 15.11		AP1B1_HUMAN (33-935): 0: 654: 15.41
+	Hs
		212604 EPS15_HUMAN (5-417): 2.05e-38: 155: 15.90		AP1G1_HUMAN (6-820): 0: 590: 22.60