HitPredict

Interactor 1: RUXE (P62304)
Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE)
Gene: SNRPE

Interactor 2: SYF1 (Q9HCS7)
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)
Gene: XAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 855
+	Hs
		911737 RUXE_HUMAN (1-92): 2.95e-48: 149: 100.00		CRNL1_HUMAN (166-822): 5.62e-47: 182: 14.51
+	Hs
		911645 RUXE_HUMAN (1-92): 2.95e-48: 149: 100.00		SART3_HUMAN (18-578): 1.7e-31: 134: 12.80
+	Hs
		300098 RUXE_HUMAN (1-92): 2.95e-48: 149: 100.00		PRP6_HUMAN (2-353): 4.69e-26: 117: 12.92
+	Sp
		1015543 RUXE_SCHPO (9-90): 7.25e-37: 120: 54.88		PRP1_SCHPO (3-435): 4.99e-19: 94.7: 13.66
+	Sc
		1015444 RUXE_YEAST (12-89): 4.26e-36: 119: 49.41		CLF1_YEAST (3-250): 5.35e-11: 68.5: 12.06