Protein: RN139
E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)

Gene: RN139, RNF139
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q8WU17

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

908870

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1138894

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1259708

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1259707

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

3

Small-scale

0.665

High

181114

INSI1
Insulin-induced gene 1 protein

3

5

Small-scale

0.640

High

891419

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.618

High

1259698

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

19

High-throughput

0.618

High

1253936

HM13
Minor histocompatibility antigen H13

2

1

Small-scale

0.612

High

529470

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

299956

ERLN2
Erlin-2

1

9

Small-scale

0.515

High

1259701

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1049606

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

7

Small-scale

0.501

High

326962

LY66D
Lymphocyte antigen 6 complex locus protein G6d

1

1

High-throughput

0.489

High

161555

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.479

High

266213

ERLN1
Erlin-1

1

7

Small-scale

0.479

High

315741

SC24B
Protein transport protein Sec24B

1

4

Small-scale

0.479

High

326885

FADS2
Acyl-CoA 6-desaturase

1

2

High-throughput

0.479

High

373140

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

11

Small-scale

0.479

High

488315

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

Small-scale

0.479

High

571818

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

579364

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

5

High-throughput

0.479

High

601316

VDAC1
Voltage-dependent anion-selective channel protein 1

1

2

High-throughput

0.479

High

1016003

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

12

Small-scale

0.479

High

1138706

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.479

High

1259699

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1259700

CCD47
PAT complex subunit CCDC47

1

3

High-throughput

0.479

High

1259702

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.479

High

1259704

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.479

High

1259705

RNF5
E3 ubiquitin-protein ligase RNF5

1

7

High-throughput

0.479

High

1259710

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1259711

INSI2
Insulin-induced gene 2 protein

1

5

Small-scale

0.479

High

1259712

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

3

Small-scale

0.479

High

421338

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.458

High

575508

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

772078

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

1016086

SRBP2
Sterol regulatory element-binding protein 2

1

0

Small-scale

0.458

High

1183847

ABHDD
Protein ABHD13

1

0

High-throughput

0.458

High

1223546

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.458

High

1259703

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.458

High

1259706

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.458

High

431256

CATB
Cathepsin B

1

1

High-throughput

0.437

High

676693

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

1

High-throughput

0.437

High

1017022

KCNH2
Potassium voltage-gated channel subfamily H member 2

1

2

Small-scale

0.437

High

1259709

TM165
Putative divalent cation/proton antiporter TMEM165

1

2

High-throughput

0.437

High

868639

ATX1
Ataxin-1

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024