HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: BIRC8 (Q96P09)
Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)
Gene: BIRC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 236
+	Hs
		1298970 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		BIRC8_HUMAN (1-236): 1.07e-86: 258: 100.00
+	Hs
		919817 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		BIRC7_HUMAN (1-236): 4.79e-61: 195: 33.47
+	Hs
		919813 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		MIB2_HUMAN (37-234): 9.33e-29: 115: 19.34
+	At
		715121 UBC8_ARATH (1-147): 8.9e-83: 241: 80.27		RGLG3_ARATH (53-234): 4.34e-24: 100: 15.61
+	Hs
		919804 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RFFL_HUMAN (64-236): 4.82e-24: 100: 17.78
+	At
		715118 UBC8_ARATH (1-147): 8.9e-83: 241: 80.27		LUL3_ARATH (86-233): 1.1e-23: 99.3: 17.76
+	Hs
		919809 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF34_HUMAN (161-236): 2.91e-23: 98: 36.84
+	Hs
		1264347 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		MYLIP_HUMAN (166-235): 7.52e-21: 92.2: 35.71
+	Hs
		849386 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		MYLIP_HUMAN (166-235): 7.52e-21: 92.2: 35.71
+	Hs
		919803 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		MYLIP_HUMAN (166-235): 7.52e-21: 92.2: 35.71
+	Hs
		849321 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		919721 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		849322 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		919722 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		957802 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		849308 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		919707 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		1206094 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		MIB1_HUMAN (158-233): 9.18e-12: 66: 25.00
+	Hs
		849363 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		MIB1_HUMAN (158-233): 9.18e-12: 66: 25.00
+	Hs
		919776 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		MIB1_HUMAN (158-233): 9.18e-12: 66: 25.00