Protein: MED4
Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4)

Gene: MED4
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: Q12343

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994568

MED7
Mediator of RNA polymerase II transcription subunit 7

16

1

Small-scale

0.984

High

704167

MED9
Mediator of RNA polymerase II transcription subunit 9

10

0

Small-scale

0.925

High

693576

MED17
Mediator of RNA polymerase II transcription subunit 17

10

0

Small-scale

0.921

High

1015457

MED1
Mediator of RNA polymerase II transcription subunit 1

9

0

Small-scale

0.917

High

581390

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.910

High

814175

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.910

High

751483

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.872

High

754292

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.831

High

748124

MED8
Mediator of RNA polymerase II transcription subunit 8

7

1

Small-scale

0.735

High

693947

MED18
Mediator of RNA polymerase II transcription subunit 18

9

0

Small-scale

0.717

High

1015071

MED2
Mediator of RNA polymerase II transcription subunit 2

6

0

Small-scale

0.691

High

772532

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.684

High

693613

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

626048

MED19
Mediator of RNA polymerase II transcription subunit 19

5

0

Small-scale

0.679

High

986574

MED10
Mediator of RNA polymerase II transcription subunit 10

5

0

Small-scale

0.676

High

586349

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.661

High

859249

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.661

High

760605

SSN3
Meiotic mRNA stability protein kinase SSN3

3

0

Small-scale

0.619

High

513243

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.584

High

686876

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.576

High

710284

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.576

High

412492

KIN28
Serine/threonine-protein kinase KIN28

2

0

Small-scale

0.569

High

758037

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.569

High

515131

TAF13
Transcription initiation factor TFIID subunit 13

2

0

High-throughput

0.563

High

991293

RXT3
Transcriptional regulatory protein RXT3

2

0

High-throughput

0.563

High

375541

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.559

High

558329

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

542161

CYC8
General transcriptional corepressor CYC8

1

0

Small-scale

0.513

High

676480

XPO1
Exportin-1

1

0

High-throughput

0.513

High

977544

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.513

High

744295

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

1

High-throughput

0.508

High

636782

CDC48
Cell division control protein 48

1

0

High-throughput

0.493

High

378250

PUR3
Phosphoribosylglycinamide formyltransferase

1

0

High-throughput

0.486

High

774094

NDC80
Kinetochore protein NDC80

1

0

High-throughput

0.486

High

988740

SWC7
SWR1-complex protein 7

1

0

High-throughput

0.486

High

381583

GAL4
Regulatory protein GAL4

1

1

Small-scale

0.479

High

523465

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

655059

CIN8
Kinesin-like protein CIN8

1

0

High-throughput

0.460

High

368763

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.458

High

525790

TOP3
DNA topoisomerase 3

1

0

High-throughput

0.458

High

636006

SRB8
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.458

High

663701

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

687769

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.458

High

715760

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728345

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

751104

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

775592

MPH1
ATP-dependent DNA helicase MPH1

1

0

High-throughput

0.458

High

812171

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

814159

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

866568

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

1014894

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

1015502

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

1015503

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

695832

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

769827

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

756892

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.438

High

1015114

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

1

Small-scale

0.437

High

1015227

POM33
Pore membrane protein of 33 kDa

1

1

Small-scale

0.437

High

355695

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

495331

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

628600

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

754819

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

975998

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

1015280

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

478616

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

766282

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

816877

SNAPN
Biogenesis of lysosome-related organelles complex 1 subunit SNN1

2

0

High-throughput

0.307

High

864525

ZRG17
Protein ZRG17

1

0

High-throughput

0.279

Low

975415

YMZ2
WD repeat-containing protein YMR102C

1

0

High-throughput

0.279

Low

733724

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.269

Low

761593

DSS1
Exoribonuclease II, mitochondrial

1

0

High-throughput

0.269

Low

778756

CIN1
Chromosome instability protein 1

1

0

High-throughput

0.269

Low

953672

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.269

Low

696840

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.265

Low

763843

RBG1
Ribosome-interacting GTPase 1

1

0

High-throughput

0.265

Low

342793

ENO1
Enolase 1

1

0

High-throughput

0.261

Low

410840

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

427311

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.261

Low

537503

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

566685

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.261

Low

588266

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

713277

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.261

Low

383414

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

413774

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

544614

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

700688

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

762679

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

811723

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

820239

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

967829

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

628688

CANB
Calcineurin subunit B

1

0

High-throughput

0.238

Low

988618

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

1015464

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024