Protein: SGS1
ATP-dependent helicase SGS1 (EC 5.6.2.4) (DNA 3'-5' helicase Sgs1) (Helicase TPS1)

Gene: SGS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P35187

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000706 - meiotic DNA double-strand break processing
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560234

TOP3
DNA topoisomerase 3

18

11

Small-scale

0.987

High

724873

RAD16
DNA repair protein RAD16

2

15

Small-scale

0.811

High

763272

SGS1
ATP-dependent helicase SGS1

1

17

Small-scale

0.724

High

763288

RMI1
RecQ-mediated genome instability protein 1

7

0

Small-scale

0.716

High

647745

RFA1
Replication factor A protein 1

4

13

Small-scale

0.710

High

763280

MLH1
DNA mismatch repair protein MLH1

5

2

Small-scale

0.704

High

763303

SMT3
Ubiquitin-like protein SMT3

4

10

Small-scale

0.692

High

763274

SWD3
COMPASS component SWD3

1

20

High-throughput

0.691

High

763287

UBC9
SUMO-conjugating enzyme UBC9

4

3

Small-scale

0.676

High

763298

SMC5
Structural maintenance of chromosomes protein 5

3

14

Small-scale

0.661

High

646363

RAD53
Serine/threonine-protein kinase RAD53

2

2

Small-scale

0.654

High

745517

MRE11
Double-strand break repair protein MRE11

3

3

Small-scale

0.653

High

763291

MSH6
DNA mismatch repair protein MSH6

3

7

Small-scale

0.650

High

763279

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

2

13

Small-scale

0.625

High

763281

MPH1
ATP-dependent DNA helicase MPH1

1

18

High-throughput

0.618

High

763304

CMR1
DNA damage-binding protein CMR1

1

19

High-throughput

0.618

High

364462

CDK1
Cyclin-dependent kinase 1

2

7

Small-scale

0.602

High

763273

ATR
Serine/threonine-protein kinase MEC1

2

14

Small-scale

0.602

High

763278

RT107
Regulator of Ty1 transposition protein 107

2

13

Small-scale

0.600

High

675324

RAD51
DNA repair protein RAD51

2

13

Small-scale

0.594

High

763295

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

19

High-throughput

0.590

High

763276

NSE2
E3 SUMO-protein ligase MMS21

2

0

Small-scale

0.577

High

557691

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.552

High

763301

MLH3
DNA mismatch repair protein MLH3

1

2

Small-scale

0.534

High

763285

STU2
Protein STU2

2

1

High-throughput

0.526

High

656741

KC12
Casein kinase I homolog 2

1

6

High-throughput

0.501

High

682911

MSH2
DNA mismatch repair protein MSH2

1

7

Small-scale

0.501

High

739947

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

12

Small-scale

0.501

High

763277

KSP1
Serine/threonine-protein kinase KSP1

1

8

High-throughput

0.501

High

763289

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

14

High-throughput

0.501

High

666165

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

Small-scale

0.481

High

700089

PRP45
Pre-mRNA-processing protein 45

1

5

Small-scale

0.481

High

763290

GIS1
Transcriptional activator/repressor GIS1

1

1

Small-scale

0.481

High

763302

RIO1
Serine/threonine-protein kinase RIO1

1

10

Small-scale

0.481

High

763297

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

763283

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

763286

DPB11
DNA replication regulator DPB11

1

9

Small-scale

0.479

High

763293

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

763294

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.479

High

763284

BUD27
Bud site selection protein 27

1

0

Small-scale

0.460

High

763296

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.460

High

763275

HSM3
DNA mismatch repair protein HSM3

1

0

High-throughput

0.458

High

763299

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.458

High

763300

DIA2
Protein DIA2

1

0

Small-scale

0.458

High

688736

RFA2
Replication factor A protein 2

1

13

Small-scale

0.457

High

392524

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.445

High

526350

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

544392

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

741307

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

763292

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

763282

DJP1
DnaJ-like protein 1

1

10

High-throughput

0.407

High

763305

MPD2
Protein disulfide isomerase MPD2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025