Protein: CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC 2.7.11.21)

Gene: CDC5
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: P32562

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739940

SWE1
Mitosis inhibitor protein kinase SWE1

6

19

Small-scale

0.945

High

734248

DBF4
DDK kinase regulatory subunit DBF4

7

0

Small-scale

0.923

High

646348

RAD53
Serine/threonine-protein kinase RAD53

4

18

Small-scale

0.908

High

739997

CDC14
Tyrosine-protein phosphatase CDC14

3

9

Small-scale

0.870

High

364416

CDK1
Cyclin-dependent kinase 1

3

4

Small-scale

0.858

High

440919

CDC7
Cell division control protein 7

3

19

Small-scale

0.855

High

734594

NUD1
Protein NUD1

3

4

Small-scale

0.845

High

739934

IME2
Meiosis induction protein kinase IME2/SME1

2

16

Small-scale

0.789

High

662080

MPIP
M-phase inducer phosphatase

2

4

Small-scale

0.778

High

740031

SCC1
Sister chromatid cohesion protein 1

10

2

Small-scale

0.755

High

739978

FKH2
Fork head protein homolog 2

1

5

Small-scale

0.734

High

739987

BFA1
Mitotic check point protein BFA1

8

0

Small-scale

0.720

High

739965

MBO1
Gamma tubulin complex adapter SPC72

8

0

Small-scale

0.719

High

739982

SMC3
Structural maintenance of chromosomes protein 3

4

5

Small-scale

0.699

High

448675

SNF1
Carbon catabolite-derepressing protein kinase

1

17

Small-scale

0.691

High

739933

RPN2
26S proteasome regulatory subunit RPN2

1

1

Small-scale

0.691

High

739994

NOP13
Nucleolar protein 13

1

3

High-throughput

0.691

High

739998

NOP3
Serine/arginine

1

2

Small-scale

0.691

High

739938

SMC1
Structural maintenance of chromosomes protein 1

3

10

Small-scale

0.675

High

739952

MMS4
Crossover junction endonuclease MMS4

4

0

Small-scale

0.665

High

740006

MUS81
Crossover junction endonuclease MUS81

3

1

Small-scale

0.664

High

739949

CENPA
Histone H3-like centromeric protein CSE4

3

10

Small-scale

0.664

High

739986

MPS3
Spindle pole body assembly component MPS3

4

0

High-throughput

0.662

High

739954

MIP6
RNA-binding protein MIP6

1

0

Small-scale

0.656

High

740017

CSA1
CDC5 pindle pole body anchor protein 1

3

1

Small-scale

0.650

High

458545

SEC4
Ras-related protein SEC4

1

5

Small-scale

0.647

High

694116

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

739932

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

17

High-throughput

0.647

High

739936

BEM3
GTPase-activating protein BEM3

1

7

Small-scale

0.647

High

739946

PP2C1
Protein phosphatase 2C homolog 1

1

14

High-throughput

0.647

High

739967

BEM2
GTPase-activating protein BEM2/IPL2

1

9

Small-scale

0.647

High

740028

CMR3
Zinc finger protein CRM3

1

3

High-throughput

0.647

High

740029

YP150
Putative serine/threonine-protein kinase YPL150W

1

19

High-throughput

0.647

High

739975

ULP2
Ubiquitin-like-specific protease 2

3

2

Small-scale

0.647

High

740032

REC8
Meiotic recombination protein REC8

3

0

Small-scale

0.642

High

739990

CDH1
APC/C activator protein CDH1

2

12

Small-scale

0.634

High

739976

SCC3
Cohesin subunit SCC3

2

1

High-throughput

0.628

High

740002

IMA1
Importin subunit alpha

2

3

Small-scale

0.628

High

740014

IMB1
Importin subunit beta-1

2

2

Small-scale

0.628

High

739983

IKS1
Probable serine/threonine-protein kinase IKS1

1

18

High-throughput

0.621

High

737073

CDC11
Cell division control protein 11

2

1

Small-scale

0.620

High

739992

CNM67
Chaotic nuclear migration protein 67

2

3

Small-scale

0.619

High

667053

CG21
G2/mitotic-specific cyclin-1

1

1

Small-scale

0.618

High

739963

TEM1
Protein TEM1

1

9

Small-scale

0.618

High

739968

BOI2
BEM1-interacting protein 2

1

6

High-throughput

0.618

High

739996

MPS1
Serine/threonine-protein kinase MPS1

1

18

Small-scale

0.618

High

740022

SLK19
Kinetochore protein SLK19

2

9

Small-scale

0.611

High

661207

SPO13
Meiosis-specific protein SPO13

2

0

Small-scale

0.595

High

739981

NET1
Nucleolar protein NET1

2

1

Small-scale

0.595

High

740027

APC9
Anaphase-promoting complex subunit 9

2

0

Small-scale

0.592

High

740033

BBP1
Spindle pole component BBP1

2

0

Small-scale

0.588

High

392430

HSP82
ATP-dependent molecular chaperone HSP82

1

16

High-throughput

0.575

High

739966

EXO1
Exodeoxyribonuclease 1

1

2

High-throughput

0.573

High

739972

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.571

High

740034

SFI1
Protein SFI1

1

0

Small-scale

0.537

High

486096

TBA1
Tubulin alpha-1 chain

1

9

Small-scale

0.536

High

556999

AAKG
5'-AMP-activated protein kinase subunit gamma

1

6

Small-scale

0.536

High

679495

CDC48
Cell division control protein 48

1

8

Small-scale

0.536

High

739935

PP12
Serine/threonine-protein phosphatase PP1-2

1

12

Small-scale

0.536

High

739941

PRS6A
26S proteasome regulatory subunit 6A

1

1

Small-scale

0.536

High

739942

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

Small-scale

0.536

High

739943

PRS7
26S proteasome regulatory subunit 7 homolog

1

7

Small-scale

0.536

High

739955

RPN1
26S proteasome regulatory subunit RPN1

1

2

Small-scale

0.536

High

739957

LSM12
Protein LSM12

1

2

Small-scale

0.536

High

739991

PRS10
26S proteasome subunit RPT4

1

7

Small-scale

0.536

High

739995

APC1
Anaphase-promoting complex subunit 1

1

2

Small-scale

0.536

High

739999

PRS8
26S proteasome regulatory subunit 8 homolog

1

2

Small-scale

0.536

High

740004

CLU
Clustered mitochondria protein 1

1

1

Small-scale

0.536

High

740007

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.536

High

740037

APC2
Anaphase-promoting complex subunit 2

1

8

Small-scale

0.536

High

740016

RSC2
Chromatin structure-remodeling complex subunit RSC2

2

9

Small-scale

0.533

High

740011

CYK2
Cytokinesis protein 2

1

4

Small-scale

0.527

High

740023

NDD1
Nuclear division defective protein 1

1

0

Small-scale

0.527

High

740003

ESP1
Separin

1

1

Small-scale

0.515

High

575035

CDC26
Anaphase-promoting complex subunit CDC26

1

0

Small-scale

0.513

High

575274

RAD9
DNA repair protein RAD9

1

0

Small-scale

0.513

High

739956

YHP7
Uncharacterized protein YHR097C

1

0

Small-scale

0.513

High

739960

SSP1
Sporulation-specific protein 1

1

0

Small-scale

0.513

High

740009

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.513

High

740012

DON1
Donuts protein 1

1

0

Small-scale

0.513

High

740019

HBT1
Protein HBT1

1

0

Small-scale

0.513

High

740030

APC11
Anaphase-promoting complex subunit 11

1

0

Small-scale

0.513

High

739980

COM1
DNA endonuclease SAE2

1

0

Small-scale

0.504

High

381961

H4
Histone H4

1

2

Small-scale

0.501

High

486764

CDC16
Anaphase-promoting complex subunit CDC16

1

11

Small-scale

0.501

High

739947

SGS1
ATP-dependent helicase SGS1

1

12

Small-scale

0.501

High

739950

CDC27
Anaphase-promoting complex subunit CDC27

1

9

Small-scale

0.501

High

739979

STU2
Protein STU2

1

8

Small-scale

0.501

High

626657

HSP60
Heat shock protein 60, mitochondrial

1

6

High-throughput

0.500

High

739971

IMB4
Importin subunit beta-4

1

2

High-throughput

0.500

High

740005

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.493

High

454288

CARP
Saccharopepsin

1

1

Small-scale

0.489

High

740036

YO21A
Transposon Ty2-OR1 Gag polyprotein

1

0

High-throughput

0.486

High

709637

BMH1
Protein BMH1

1

13

High-throughput

0.481

High

737295

CDC12
Cell division control protein 12

1

1

Small-scale

0.481

High

739989

NBP1
NAP1-binding protein

1

1

High-throughput

0.481

High

739945

SLD2
DNA replication regulator SLD2

1

0

Small-scale

0.480

High

739948

CENPC
Inner kinetochore subunit MIF2

1

0

Small-scale

0.480

High

739953

SWC5
SWR1-complex protein 5

1

0

High-throughput

0.480

High

740013

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.480

High

618900

ARF2
ADP-ribosylation factor 2

1

3

High-throughput

0.479

High

686883

BUB2
Mitotic check point protein BUB2

1

4

Small-scale

0.479

High

699938

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

High-throughput

0.479

High

735976

SP110
Spindle pole body component 110

1

12

Small-scale

0.479

High

739958

RT107
Regulator of Ty1 transposition protein 107

1

5

Small-scale

0.479

High

739959

SPC97
Spindle pole body component SPC97

1

2

Small-scale

0.479

High

739962

MLH1
DNA mismatch repair protein MLH1

1

1

High-throughput

0.479

High

739964

ATC3
Phospholipid-transporting ATPase DRS2

1

2

Small-scale

0.479

High

739974

NDC80
Kinetochore protein NDC80

1

17

Small-scale

0.479

High

739985

MTR4
ATP-dependent RNA helicase DOB1

1

4

High-throughput

0.479

High

739993

IPI3
Pre-rRNA-processing protein IPI3

1

3

High-throughput

0.479

High

740015

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

7

Small-scale

0.479

High

740026

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.479

High

740024

PRM3
Pheromone-regulated membrane protein 3

1

0

High-throughput

0.460

High

150274

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

672576

YCP4
Flavoprotein-like protein YCP4

1

0

High-throughput

0.458

High

739937

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.458

High

739939

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

739973

FDO1
Protein FDO1

1

0

High-throughput

0.458

High

739977

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

740018

DTD
D-aminoacyl-tRNA deacylase

1

0

High-throughput

0.458

High

740020

GSHB
Glutathione synthetase GSH2

1

0

High-throughput

0.458

High

740021

SGO1
Shugoshin

1

0

High-throughput

0.458

High

740025

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

734346

YMC1
Mitochondrial glycine transporter YMC1

1

5

High-throughput

0.457

High

740035

ISA2
Iron-sulfur assembly protein 2

1

1

High-throughput

0.457

High

510313

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

523385

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

454617

PROF
Profilin

1

1

High-throughput

0.437

High

740000

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.437

High

740001

UTP6
U3 small nucleolar RNA-associated protein 6

1

1

High-throughput

0.437

High

739961

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.426

High

740008

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.426

High

740010

IVY1
Protein IVY1

2

0

High-throughput

0.328

High

726021

LDS1
Outer spore wall protein LDS1

1

0

Small-scale

0.279

Low

739951

GIP1
GLC7-interacting protein 1

1

0

Small-scale

0.279

Low

739988

YD186
Uncharacterized protein YDL186W

1

0

Small-scale

0.279

Low

561300

DPOLA
DNA polymerase alpha catalytic subunit A

1

0

Small-scale

0.261

Low

739984

IRC8
Uncharacterized protein IRC8

1

0

High-throughput

0.261

Low

739969

GTT3
Glutathione transferase 3

1

0

High-throughput

0.251

Low

739944

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.249

Low

739970

VTC1
Vacuolar transporter chaperone complex subunit 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025