HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 19250909, 25270598, 29958295, 30349055, 12481031, 33504946, 36964131, 15448697, 20027226, 19256485, 25278611, 26100637, 26286618, 34878901, 35563538, 15601839, 11861641, 19818716, 22405651, 12684064 and 5 others

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Identification Methods enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 108
Hs

1 768
+ Dm
+ At
+ At
+ Mm
+ Hs
+ Mm
+ Hs
+ Dm
+ At
+ At
+ Mm
+ Hs
+ Hs
+ Dm
+ Sp
+ Sp
+ Dm
+ Ce
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024