HitPredict

Interactor 1: PGTB2 (P53611)
Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)
Gene: RABGGTB

Interactor 2: PGTA (Q92696)
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
Gene: RABGGTA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.964

The method score is based on:

Property Details
Experiments 32296183, 33961781, 35271311, 26186194, 28514442, unassigned1304, unassigned3799
Identification Methods two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PPTA~Prenyltrans
Common GO terms GO:0004663 - Rab geranylgeranyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005968 - Rab-protein geranylgeranyltransferase complex
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 331
Hs

1 567
+ Rn
+ Dm
+ Hs
+ Sc
+ Dm
+ Ce
+ Hs
+ Hs
+ Rn
+ Hs
+ Dm
+ Rn
+ Dm
+ Sp
+ At
+ Sc
+ Sp
+ Sc
+ Ce
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025