HitPredict

Interactor 1: GBB2 (P62879)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)
Gene: GNB2

Interactor 2: PHLP (Q13371)
Phosducin-like protein (PHLP)
Gene: PDCL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 33961781, 37689310, 19376773
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Phosducin~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 340 Hs			1 301
+	Hs
		1032876 GBB4_HUMAN (1-340): 3.14e-110: 326: 90.00		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		560877 GBB3_HUMAN (1-340): 2.27e-106: 316: 80.88		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		920955 GBB1_HUMAN (1-340): 1.35e-106: 316: 90.29		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Dm
		640826 GBB1_DROME (1-340): 1.91e-106: 316: 81.47		PHLP_DROME (1-277): 9.39e-89: 267: 44.41
+	Bt
		586005 GBB1_BOVIN (1-340): 1.35e-106: 316: 90.29		PHOS_BOVIN (51-291): 6.2e-75: 231: 46.89
+	Hs
		921720 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		PDCL3_HUMAN (74-301): 5.67e-67: 210: 26.78
+	Ce
		567435 GBB1_CAEEL (1-340): 8.03e-106: 315: 85.29		Q9U1X7_CAEEL (4-269): 1.69e-59: 192: 27.14
+	Hs
		154679 GNB5_HUMAN (129-340): 2.36e-44: 158: 20.81		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		147235 GBB2_HUMAN (1-340): 2.89e-111: 328: 100.00		TXND9_HUMAN (104-287): 1.42e-50: 168: 18.85
+	Hs
		1032854 POC1A_HUMAN (3-125): 4.59e-25: 106: 16.92		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Sc
		579444 GBB_YEAST (2-340): 5.29e-76: 241: 36.01		PLP1_YEAST (97-301): 2.51e-45: 154: 20.36
+	Sc
		579445 GBB_YEAST (2-340): 5.29e-76: 241: 36.01		PLP2_YEAST (71-301): 1.5e-43: 152: 15.66
+	Hs
		1240457 POC1A_HUMAN (3-125): 4.59e-25: 106: 16.92		PDCL3_HUMAN (74-301): 5.67e-67: 210: 26.78
+	Hs
		147268 POC1A_HUMAN (3-125): 4.59e-25: 106: 16.92		TXND9_HUMAN (104-287): 1.42e-50: 168: 18.85