Protein: FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)

Gene: FNTA
Organism: Homo sapiens
Interactions: 77
UniProt ID: P49354

Gene Ontology (top 5):
GO:0004660 - protein farnesyltransferase activity
GO:0004661 - protein geranylgeranyltransferase activity
GO:0004662 - CAAX-protein geranylgeranyltransferase activity
GO:0004663 - Rab geranylgeranyltransferase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881641

FNTB
Protein farnesyltransferase subunit beta

11

20

Small-scale

0.979

High

881645

PGTB1
Geranylgeranyl transferase type-1 subunit beta

5

20

High-throughput

0.924

High

881660

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

6

0

High-throughput

0.704

High

881658

TP4A2
Protein tyrosine phosphatase type IVA 2

3

2

High-throughput

0.662

High

881646

NP1L1
Nucleosome assembly protein 1-like 1

3

0

High-throughput

0.638

High

881686

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

3

0

High-throughput

0.638

High

457061

CAN1
Calpain-1 catalytic subunit

2

1

High-throughput

0.628

High

881656

RL18
Large ribosomal subunit protein eL18

2

0

High-throughput

0.602

High

881674

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

High-throughput

0.602

High

881684

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

2

0

High-throughput

0.602

High

881685

E41L5
Band 4.1-like protein 5

2

0

High-throughput

0.602

High

881689

TSKS
Testis-specific serine kinase substrate

2

0

High-throughput

0.602

High

125827

AP4M1
AP-4 complex subunit mu-1

2

0

High-throughput

0.580

High

881642

CENPF
Centromere protein F

2

0

High-throughput

0.576

High

881655

FAK1
Focal adhesion kinase 1

2

0

High-throughput

0.576

High

881680

SPDLY
Protein Spindly

2

0

High-throughput

0.576

High

76287

B4DL54
Protein farnesyltransferase subunit beta

1

20

High-throughput

0.575

High

881648

CDC42
Cell division control protein 42 homolog

2

1

High-throughput

0.571

High

787362

TGFR1
TGF-beta receptor type-1

1

1

Small-scale

0.549

High

881640

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.546

High

881688

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.537

High

192212

YKT6
Synaptobrevin homolog YKT6

1

2

High-throughput

0.536

High

605974

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.536

High

881676

RAB2B
Ras-related protein Rab-2B

1

8

High-throughput

0.536

High

881679

TP4A1
Protein tyrosine phosphatase type IVA 1

1

2

High-throughput

0.536

High

563415

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

881643

STAT2
Signal transducer and activator of transcription 2

1

0

High-throughput

0.518

High

881661

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.518

High

719416

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

0

High-throughput

0.513

High

881649

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

881652

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.513

High

881659

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.513

High

881662

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.513

High

881670

CENPV
Centromere protein V

1

0

High-throughput

0.513

High

881671

RIOX2
Ribosomal oxygenase 2

1

0

High-throughput

0.513

High

881672

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.513

High

881673

OGFD1
Prolyl 3-hydroxylase OGFOD1

1

0

High-throughput

0.513

High

881675

RN169
E3 ubiquitin-protein ligase RNF169

1

0

High-throughput

0.513

High

881677

SNX33
Sorting nexin-33

1

0

High-throughput

0.513

High

881681

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.513

High

881687

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.513

High

881691

T53G5
TP53-target gene 5 protein

1

0

High-throughput

0.513

High

185515

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

483486

INHBB
Inhibin beta B chain

1

1

High-throughput

0.494

High

881644

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.486

High

376757

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

Small-scale

0.481

High

881654

ACVR1
Activin receptor type-1

1

1

Small-scale

0.481

High

241066

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

277329

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.479

High

881668

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

642528

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

824046

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.460

High

881657

GRSF1
G-rich sequence factor 1

1

0

Small-scale

0.460

High

315274

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

651222

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

712159

TKT
Transketolase

1

0

High-throughput

0.458

High

881678

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

881690

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

881650

RRAS2
Ras-related protein R-Ras2

1

6

High-throughput

0.445

High

404724

PRIO
Major prion protein

1

0

High-throughput

0.426

High

593945

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.426

High

881651

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.426

High

881683

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.426

High

881666

AMERL
AMMECR1-like protein

4

0

High-throughput

0.360

High

881667

F117B
Protein FAM117B

2

0

High-throughput

0.328

High

881669

CEFIP
Cardiac-enriched FHL2-interacting protein

2

0

High-throughput

0.328

High

871163

TFPI2
Tissue factor pathway inhibitor 2

1

0

High-throughput

0.279

Low

881647

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.279

Low

881653

LMNB2
Lamin-B2

1

0

High-throughput

0.279

Low

881663

ZMYM1
Zinc finger MYM-type protein 1

1

0

High-throughput

0.279

Low

881664

ZN691
Zinc finger protein 691

1

0

High-throughput

0.279

Low

881682

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

105557

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

881692

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.249

Low

135791

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.232

Low

881665

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025