HitPredict

Interactor 1: FNTA (P49354)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Gene: FNTA

Interactor 2: PGTB1 (P53609)
Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
Gene: PGGT1B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 32296183, 24981860, 33961781, unassigned1304, unassigned3799
Identification Methods two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PPTA~Prenyltrans
Common GO terms GO:0004661 - protein geranylgeranyltransferase activity
GO:0004662 - CAAX-protein geranylgeranyltransferase activity
GO:0005953 - CAAX-protein geranylgeranyltransferase complex
GO:0018344 - protein geranylgeranylation
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 379
Hs

1 377
+ Rn
+ Dm
+ Hs
+ Hs
+ Rn
+ Ce
+ At
+ Ce
+ Dm
+ Hs
+ Sp
+ Rn
+ Sp
+ Hs
+ Sc
+ Sc
+ Dm
+ Sc
+ Dm
+ At

Service provided by Combinatics, Japan

Last updated: 11Aug2025