HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DAG1 (Q14118)
Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
Gene: DAG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	7744812, 17474147
Identification Methods	pull down, affinity chromatography technology, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 895
+	Oc
		101982 G1SR27_RABIT (1-217): 6.71e-76: 229: 100.00		DAG1_RABIT (1-895): 9.3e-162: 497: 93.74
+	Hs
		782787 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		DAG1_HUMAN (1-895): 7.39e-154: 476: 100.00
+	Hs
		557685 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DAG1_HUMAN (1-895): 7.39e-154: 476: 100.00
+	Hs
		412189 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DAG1_HUMAN (1-895): 7.39e-154: 476: 100.00
+	Hs
		522977 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		DAG1_HUMAN (1-895): 7.39e-154: 476: 100.00
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (67-890): 1.18e-26: 119: 9.42
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (180-822): 3.46e-23: 108: 13.52
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (350-894): 1.68e-13: 76.9: 13.21
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (67-890): 1.18e-26: 119: 9.42
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (180-822): 3.46e-23: 108: 13.52
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (67-890): 1.18e-26: 119: 9.42
+	Mm
		101430 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		F8VPR5_MOUSE (175-582): 1.7e-22: 106: 11.28
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (180-822): 3.46e-23: 108: 13.52
+	Hs
		433560 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC1_HUMAN (67-890): 1.18e-26: 119: 9.42
+	Hs
		522749 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MUC1_HUMAN (67-890): 1.18e-26: 119: 9.42
+	Hs
		203228 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		SYNJ1_HUMAN (180-822): 3.46e-23: 108: 13.52
+	Mm
		101424 LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47		F8VPR5_MOUSE (175-582): 1.7e-22: 106: 11.28
+	Hs
		297808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		K0754_HUMAN (548-894): 8.16e-11: 68.4: 15.10
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (93-838): 8.88e-10: 65.3: 11.87