HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24642916
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 370
+	Hs
		924877 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		782823 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		412347 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		523136 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		411818 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		789096 ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Hs
		411561 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CD48_HUMAN (28-247): 2.6e-46: 160: 22.42
+	Hs
		411547 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		924478 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PGBM_HUMAN (134-307): 1.74e-09: 61.9: 10.81
+	Mm
		763408 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		412176 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		454828 FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		523015 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		CEA21_HUMAN (6-280): 1.9e-50: 172: 16.78
+	Hs
		411939 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		CD2_HUMAN (9-356): 1.48e-44: 158: 13.24
+	Hs
		433317 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Hs
		433691 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		CXAR_HUMAN (2-358): 7.84e-45: 159: 14.84
+	Dm
		219802 ABL_DROME (4-135): 1e-22: 97.4: 37.68		O44924_DROME (135-312): 8.74e-13: 71.9: 8.65
+	Hs
		433742 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PTK7_HUMAN (31-353): 1.31e-19: 92.7: 11.47
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (39-226): 3.55e-09: 60.7: 11.06