Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2
Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 1.00 | 0.887 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 9856458, 32296183, 9742218, unassigned1304 |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, two hybrid array, validated two hybrid, two hybrid prey pooling approach |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | SH2~SH2, PH~SH3_1, SH2~SH3_1 |
| Common GO terms | GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
