Protein: ENL
Protein ENL (YEATS domain-containing protein 1)

Gene: ENL, MLLT1
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q03111

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0008023 - transcription elongation factor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

908270

AFF1
AF4/FMR2 family member 1

8

20

Small-scale

0.970

High

1040765

AFF4
AF4/FMR2 family member 4

7

17

Small-scale

0.970

High

839880

AF9
Protein AF-9

6

10

Small-scale

0.940

High

897753

CDK9
Cyclin-dependent kinase 9

15

17

Small-scale

0.762

High

137328

ELL2
RNA polymerase II elongation factor ELL2

4

15

Small-scale

0.699

High

1040746

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

4

3

Small-scale

0.694

High

908297

AFF3
AF4/FMR2 family member 3

1

17

High-throughput

0.691

High

1040760

ELL3
RNA polymerase II elongation factor ELL3

4

10

High-throughput

0.691

High

1040731

BCOR
BCL-6 corepressor

3

12

Small-scale

0.667

High

1040749

EAF1
ELL-associated factor 1

3

1

High-throughput

0.667

High

871922

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

1

High-throughput

0.662

High

1040761

CBX8
Chromobox protein homolog 8

3

12

Small-scale

0.661

High

936508

AF10
Protein AF-10

3

11

Small-scale

0.658

High

217425

E41L2
Band 4.1-like protein 2

2

14

High-throughput

0.628

High

251572

CCNT1
Cyclin-T1

2

8

Small-scale

0.628

High

732553

ARRB2
Beta-arrestin-2

2

2

High-throughput

0.628

High

1040735

YAF2
YY1-associated factor 2

2

2

High-throughput

0.628

High

1040738

RYBP
RING1 and YY1-binding protein

2

2

High-throughput

0.628

High

1040753

PCGF1
Polycomb group RING finger protein 1

2

13

Small-scale

0.628

High

1040757

DEN2D
DENN domain-containing protein 2D

2

1

High-throughput

0.628

High

1040739

PAF1
RNA polymerase II-associated factor 1 homolog

2

2

Small-scale

0.624

High

936589

ELL
RNA polymerase II elongation factor ELL

2

10

Small-scale

0.611

High

964868

WDR5
WD repeat-containing protein 5

2

9

Small-scale

0.585

High

979530

H4
Histone H4

2

9

Small-scale

0.584

High

1040741

CAMKV
CaM kinase-like vesicle-associated protein

2

2

High-throughput

0.574

High

1040745

BPIB1
BPI fold-containing family B member 1

2

1

High-throughput

0.574

High

395954

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1040747

ESR2
Estrogen receptor beta

2

20

High-throughput

0.571

High

765420

BMI1
Polycomb complex protein BMI-1

1

13

Small-scale

0.561

High

936542

AF17
Protein AF-17

2

10

Small-scale

0.558

High

1040740

SYT2
Synaptotagmin-2

2

3

High-throughput

0.549

High

252242

CCNT2
Cyclin-T2

1

8

High-throughput

0.536

High

711761

ARI4A
AT-rich interactive domain-containing protein 4A

1

3

High-throughput

0.536

High

992144

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.536

High

1040719

KMT2A
Histone-lysine N-methyltransferase 2A

1

13

Small-scale

0.536

High

1040727

ARI4B
AT-rich interactive domain-containing protein 4B

1

5

High-throughput

0.536

High

1040750

CEP89
Centrosomal protein of 89 kDa

1

13

High-throughput

0.536

High

1040752

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

4

High-throughput

0.536

High

1040756

E41L1
Band 4.1-like protein 1

1

14

High-throughput

0.536

High

1040762

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

5

High-throughput

0.536

High

1040766

E41L3
Band 4.1-like protein 3

1

14

High-throughput

0.536

High

839543

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

1040742

R3GEF
Guanine nucleotide exchange factor for Rab-3A

1

0

High-throughput

0.513

High

1040743

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

595404

H15
Histone H1.5

1

6

Small-scale

0.501

High

1040723

H31T
Histone H3.1t

1

20

Small-scale

0.501

High

1040767

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.493

High

706104

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

961162

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.489

High

1040733

SPA12
Serpin A12

1

1

High-throughput

0.489

High

1040737

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

4

High-throughput

0.489

High

899844

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.481

High

140880

NOP56
Nucleolar protein 56

1

4

High-throughput

0.479

High

160074

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

6

Small-scale

0.479

High

180792

TIF1A
Transcription intermediary factor 1-alpha

1

19

High-throughput

0.479

High

190880

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

259823

BRD4
Bromodomain-containing protein 4

1

19

Small-scale

0.479

High

335983

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.479

High

459553

PROF1
Profilin-1

1

4

Small-scale

0.479

High

487211

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

591607

H2AX
Histone H2AX

1

11

Small-scale

0.479

High

606661

CEBPB
CCAAT/enhancer-binding protein beta

1

19

High-throughput

0.479

High

667275

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

799857

COIL
Coilin

1

2

High-throughput

0.479

High

872229

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.479

High

883511

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

889554

CLK2
Dual specificity protein kinase CLK2

1

13

High-throughput

0.479

High

889712

CLK3
Dual specificity protein kinase CLK3

1

14

High-throughput

0.479

High

920788

ACLY
ATP-citrate synthase

1

1

High-throughput

0.479

High

986356

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

997657

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.479

High

998232

H31
Histone H3.1

1

20

High-throughput

0.479

High

1025449

CDK5
Cyclin-dependent kinase 5

1

6

High-throughput

0.479

High

1029803

RUNX1
Runt-related transcription factor 1

1

7

High-throughput

0.479

High

1039480

TOP2B
DNA topoisomerase 2-beta

1

4

High-throughput

0.479

High

1040721

ACACA
Acetyl-CoA carboxylase 1

1

3

Small-scale

0.479

High

1040725

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.479

High

1040729

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1040730

CDC73
Parafibromin

1

5

Small-scale

0.479

High

1040734

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1040736

SLX4
Structure-specific endonuclease subunit SLX4

1

17

High-throughput

0.479

High

1040748

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

8

Small-scale

0.479

High

1040751

RING2
E3 ubiquitin-protein ligase RING2

1

15

Small-scale

0.479

High

1040754

DDX23
Probable ATP-dependent RNA helicase DDX23

1

11

High-throughput

0.479

High

1040755

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1040758

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1040759

SP110
Sp110 nuclear body protein

1

20

High-throughput

0.479

High

1040764

CDK12
Cyclin-dependent kinase 12

1

15

High-throughput

0.479

High

1040768

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1040769

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

1040763

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

2

Small-scale

0.464

High

716833

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

871821

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.458

High

914587

RM12
Large ribosomal subunit protein bL12m

1

0

Small-scale

0.458

High

584084

FOSL2
Fos-related antigen 2

1

20

High-throughput

0.445

High

1040720

BTK
Tyrosine-protein kinase BTK

1

14

High-throughput

0.445

High

889400

CLK1
Dual specificity protein kinase CLK1

1

16

High-throughput

0.437

High

1040722

CDK10
Cyclin-dependent kinase 10

1

7

High-throughput

0.437

High

1040724

H2A2C
Histone H2A type 2-C

1

11

Small-scale

0.437

High

1040732

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1040744

SP7
Transcription factor Sp7

1

20

High-throughput

0.437

High

325541

YIF1A
Protein YIF1A

2

0

High-throughput

0.316

High

130874

RFXAP
Regulatory factor X-associated protein

1

0

Small-scale

0.249

Low

1040726

Q2Q440
MLL/ENL fusion protein

1

0

Small-scale

0.249

Low

1040728

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025