Protein: AF9
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)

Gene: AF9, MLLT3
Organism: Homo sapiens
Interactions: 91
UniProt ID: P42568

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839869

AFF1
AF4/FMR2 family member 1

6

11

Small-scale

0.950

High

839930

AFF4
AF4/FMR2 family member 4

6

10

Small-scale

0.946

High

839880

ENL
Protein ENL

6

10

Small-scale

0.940

High

839868

CDK9
Cyclin-dependent kinase 9

13

8

Small-scale

0.760

High

839909

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

12

4

Small-scale

0.760

High

839870

AFF3
AF4/FMR2 family member 3

2

10

Small-scale

0.754

High

839922

ELL3
RNA polymerase II elongation factor ELL3

6

10

Small-scale

0.727

High

839873

ELL
RNA polymerase II elongation factor ELL

6

10

Small-scale

0.726

High

839899

BCOR
BCL-6 corepressor

5

13

Small-scale

0.724

High

839914

EAF1
ELL-associated factor 1

5

1

Small-scale

0.718

High

137319

ELL2
RNA polymerase II elongation factor ELL2

4

12

Small-scale

0.694

High

839872

AF17
Protein AF-17

3

7

Small-scale

0.675

High

839911

EDA
Ectodysplasin-A

3

1

High-throughput

0.667

High

839921

DEN2D
DENN domain-containing protein 2D

3

1

High-throughput

0.667

High

251530

CCNT1
Cyclin-T1

3

4

Small-scale

0.656

High

839910

APBP2
Amyloid protein-binding protein 2

3

0

High-throughput

0.639

High

839925

EXOS3
Exosome complex component RRP40

3

0

High-throughput

0.638

High

217401

E41L2
Band 4.1-like protein 2

2

13

High-throughput

0.628

High

640574

MK
Midkine

2

1

High-throughput

0.628

High

732465

ARRB2
Beta-arrestin-2

2

2

High-throughput

0.628

High

839866

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

1

High-throughput

0.628

High

839908

BPIB1
BPI fold-containing family B member 1

2

1

High-throughput

0.628

High

839924

E41L5
Band 4.1-like protein 5

2

14

High-throughput

0.628

High

839931

E41L3
Band 4.1-like protein 3

2

14

High-throughput

0.628

High

839865

AF9
Protein AF-9

1

12

High-throughput

0.621

High

252232

CCNT2
Cyclin-T2

2

4

Small-scale

0.611

High

839871

AF10
Protein AF-10

2

8

Small-scale

0.611

High

839918

PCGF1
Polycomb group RING finger protein 1

2

11

Small-scale

0.611

High

839893

VAX1
Ventral anterior homeobox 1

2

2

High-throughput

0.606

High

839900

ZN572
Zinc finger protein 572

2

1

High-throughput

0.606

High

839926

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

3

1

Small-scale

0.604

High

139494

PESC
Pescadillo homolog

2

0

High-throughput

0.602

High

839878

H33
Histone H3.3

1

16

Small-scale

0.586

High

839881

KMT2A
Histone-lysine N-methyltransferase 2A

2

9

Small-scale

0.584

High

839907

CAMKV
CaM kinase-like vesicle-associated protein

2

2

High-throughput

0.574

High

839932

SNX24
Sorting nexin-24

2

2

High-throughput

0.574

High

573369

ENPL
Endoplasmin

1

6

Small-scale

0.561

High

839923

CBX8
Chromobox protein homolog 8

1

7

Small-scale

0.561

High

839877

H31
Histone H3.1

1

16

Small-scale

0.550

High

839879

CDK6
Cyclin-dependent kinase 6

1

5

Small-scale

0.550

High

839876

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.541

High

839885

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.541

High

839892

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

Small-scale

0.536

High

335966

MED26
Mediator of RNA polymerase II transcription subunit 26

1

2

High-throughput

0.536

High

839874

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.536

High

839875

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.536

High

839888

RASA2
Ras GTPase-activating protein 2

1

3

High-throughput

0.536

High

839889

RN151
RING finger protein 151

1

1

High-throughput

0.536

High

839896

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

1

High-throughput

0.536

High

839912

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.536

High

839915

CEP89
Centrosomal protein of 89 kDa

1

12

High-throughput

0.536

High

839917

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

5

High-throughput

0.536

High

839920

E41L1
Band 4.1-like protein 1

1

13

High-throughput

0.536

High

839867

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

839891

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

839927

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.513

High

839929

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

421659

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

839898

CDC73
Parafibromin

1

3

Small-scale

0.500

High

636714

PTN
Pleiotrophin

1

1

High-throughput

0.494

High

839904

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

5

High-throughput

0.489

High

839906

SYT2
Synaptotagmin-2

1

3

High-throughput

0.489

High

122927

SGK1
Serine/threonine-protein kinase Sgk1

1

0

Small-scale

0.480

High

142883

NFIB
Nuclear factor 1 B-type

1

9

High-throughput

0.479

High

172544

XPO1
Exportin-1

1

6

High-throughput

0.479

High

279295

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

473842

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.479

High

565805

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

606374

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

799783

COIL
Coilin

1

2

High-throughput

0.479

High

839882

NFIA
Nuclear factor 1 A-type

1

11

High-throughput

0.479

High

839883

ACACA
Acetyl-CoA carboxylase 1

1

1

Small-scale

0.479

High

839884

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.479

High

839886

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

3

Small-scale

0.479

High

839887

NFIX
Nuclear factor 1 X-type

1

13

High-throughput

0.479

High

839897

NIPBL
Nipped-B-like protein

1

6

Small-scale

0.479

High

839903

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.479

High

839905

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

Small-scale

0.479

High

839913

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.479

High

839916

RING2
E3 ubiquitin-protein ligase RING2

1

12

Small-scale

0.479

High

839894

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

839895

RIF1
Telomere-associated protein RIF1

1

7

High-throughput

0.457

High

839933

TRRAP
Transformation/transcription domain-associated protein

1

6

Small-scale

0.445

High

839902

FAM9A
Protein FAM9A

5

0

High-throughput

0.374

High

839890

MIIP
Migration and invasion-inhibitory protein

3

0

High-throughput

0.346

High

839901

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

839919

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.279

Low

839934

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

516085

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

839928

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025