HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 299
+	Hs
		951263 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		894352 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		718731 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646166 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		564417 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		545232 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		545212 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		719140 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646300 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		718752 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		718676 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646156 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		646171 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		646157 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		718686 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646160 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		436164 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93