HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N
Common GO terms	GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 263
+	Dm
		820516 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q9VK14_DROME (1-263): 3.32e-100: 295: 49.81
+	Dm
		522484 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA1_DROME (1-260): 4.06e-99: 292: 52.42
+	Hs
		572856 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Dm
		820495 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA5_DROME (1-237): 4.05e-92: 273: 28.86
+	Dm
		522492 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA1_DROME (1-260): 4.06e-99: 292: 52.42
+	Hs
		92605 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81
+	Hs
		92615 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Hs
		156216 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19
+	Hs
		92604 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Dm
		522505 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA1_DROME (1-260): 4.06e-99: 292: 52.42
+	Dm
		1181022 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA5_DROME (1-237): 4.05e-92: 273: 28.86
+	Hs
		572863 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81
+	Hs
		572911 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Hs
		572859 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Dm
		1278637 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA5_DROME (1-237): 4.05e-92: 273: 28.86
+	Sc
		703803 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		PSA6_YEAST (1-233): 3.26e-83: 250: 52.77
+	Sc
		703642 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		PSA6_YEAST (1-233): 3.26e-83: 250: 52.77
+	Dm
		611634 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA71_DROME (4-233): 2.4e-38: 136: 33.48
+	Dm
		611645 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA71_DROME (4-233): 2.4e-38: 136: 33.48
+	Dm
		611654 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA71_DROME (4-233): 2.4e-38: 136: 33.48