HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSB3 (P49720)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
Gene: PSMB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~Proteasome
Common GO terms	GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 205
+	Dm
		771398 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSB1_DROME (2-205): 3.62e-70: 215: 26.51
+	Dm
		820535 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSB3_DROME (1-205): 1.69e-67: 207: 63.90
+	Dm
		820480 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q7K148_DROME (8-195): 1.2e-65: 205: 23.94
+	Dm
		47601 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		A0AQH0_DROME (7-199): 4.68e-66: 204: 24.35
+	Hs
		92606 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68
+	Dm
		771405 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSB1_DROME (2-205): 3.62e-70: 215: 26.51
+	Hs
		572894 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00
+	Hs
		92607 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63
+	Hs
		572865 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68
+	Hs
		92600 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94
+	Dm
		1181072 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSB3_DROME (1-205): 1.69e-67: 207: 63.90
+	Hs
		92602 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85
+	Hs
		92605 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20
+	Dm
		1178941 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		Q7K148_DROME (8-195): 1.2e-65: 205: 23.94
+	Dm
		47608 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		A0AQH0_DROME (7-199): 4.68e-66: 204: 24.35
+	Hs
		572866 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63
+	Hs
		572853 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94
+	Hs
		572857 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85
+	Hs
		572863 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20
+	Hs
		572862 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB9_HUMAN (6-200): 1.41e-63: 197: 23.08