HitPredict

Interactor 1: THA (P63058)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (c-erbA-1) (c-erbA-alpha)
Gene: Thra

Interactor 2: Q8BK32 (Q8BK32)
Nuclear receptor corepressor 1
Gene: Ncor1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	21389087, 7566114
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 492 Mm			1 291
+	Hs
		261382 THA_HUMAN (1-492): 3.34e-156: 455: 95.73		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		500454 THA_HUMAN (1-492): 3.34e-156: 455: 95.73		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		261399 RXRA_HUMAN (3-408): 9.15e-115: 347: 24.09		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		261369 ESR1_HUMAN (1-432): 2.72e-109: 338: 20.13		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		261383 THB_HUMAN (22-407): 1.47e-107: 329: 71.24		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		261429 HNF4A_HUMAN (1-411): 4.88e-107: 328: 22.82		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		261450 NR1H2_HUMAN (2-407): 1.52e-105: 324: 23.85		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		818890 RXRG_HUMAN (9-411): 4.02e-115: 349: 24.01		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		261390 RARG_HUMAN (6-441): 3.27e-105: 323: 29.35		NCOR1_HUMAN (1-290): 3.09e-132: 415: 92.07
+	Hs
		587211 RXRA_HUMAN (3-408): 9.15e-115: 347: 24.09		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		500380 RARB_HUMAN (5-441): 2.39e-113: 344: 30.37		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		370824 ESR1_HUMAN (1-432): 2.72e-109: 338: 20.13		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		1069095 Q15156_HUMAN (51-383): 3.86e-106: 335: 37.54		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		500510 THB_HUMAN (22-407): 1.47e-107: 329: 71.24		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Hs
		782706 HNF4A_HUMAN (1-411): 4.88e-107: 328: 22.82		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Xl
		546248 THAA_XENLA (1-409): 1.84e-114: 345: 74.82		Q1W3Z6_XENLA (4-290): 1.92e-116: 370: 51.21
+	Xl
		546251 THAA_XENLA (1-409): 1.84e-114: 345: 74.82		NCOR1_XENLA (1-290): 2.65e-116: 369: 71.72
+	Mm
		740772 THB_MOUSE (22-407): 1.48e-107: 329: 70.47		Q8BK32_MOUSE (1-291): 4.73e-135: 385: 100.00
+	Hs
		874405 NR1H2_HUMAN (2-407): 1.52e-105: 324: 23.85		NCOR2_HUMAN (1-290): 1.65e-123: 390: 52.40
+	Xl
		574911 THBA_XENLA (35-407): 1.71e-114: 344: 75.60		NCOR1_XENLA (1-290): 2.65e-116: 369: 71.72