HitPredict

Interactor 1: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Interactor 2: ECT2 (Q9H8V3)
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Gene: ECT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31586073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 394 Hs			1 914
+	Hs
		391464 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		750016 GNAL_HUMAN (1-394): 6.97e-158: 451: 76.26		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		926712 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		444790 GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		451036 GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		67807 GNAT3_HUMAN (9-394): 7.87e-150: 429: 39.79		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		670486 GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		837608 GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02		AKP13_HUMAN (274-912): 7.43e-83: 295: 13.83
+	Hs
		837658 GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02		ARHGC_HUMAN (316-874): 1.5e-78: 281: 16.35
+	Hs
		167075 GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02		ARHGB_HUMAN (453-651): 2.54e-12: 73.2: 23.53