Protein: HIR1
Protein HIR1 (Histone transcription regulator 1)

Gene: HIR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 60
UniProt ID: P32479

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000417 - HIR complex
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

736614

ASF1
Histone chaperone ASF1

9

18

Small-scale

0.971

High

737621

HIR2
Protein HIR2

7

16

Small-scale

0.963

High

737620

HIR1
Protein HIR1

3

15

Small-scale

0.839

High

737649

HPC2
Histone promoter control protein 2

7

9

Small-scale

0.741

High

737639

HIR3
Histone transcription regulator 3

5

3

Small-scale

0.706

High

737647

H3
Histone H3

5

20

Small-scale

0.699

High

381950

H4
Histone H4

4

13

Small-scale

0.672

High

737633

UTP7
U3 small nucleolar RNA-associated protein 7

1

18

High-throughput

0.618

High

737659

CMR1
DNA damage-binding protein CMR1

1

18

High-throughput

0.618

High

737635

RT106
Histone chaperone RTT106

2

3

Small-scale

0.594

High

737623

SWI3
SWI/SNF complex subunit SWI3

2

15

Small-scale

0.588

High

577538

CYC8
General transcriptional corepressor CYC8

1

12

Small-scale

0.573

High

523367

HSP71
Heat shock protein SSA1

2

14

High-throughput

0.571

High

737627

MAC1
Metal-binding activator 1

1

0

Small-scale

0.549

High

614806

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

11

Small-scale

0.515

High

643613

SNF2
Transcription regulatory protein SNF2

1

20

Small-scale

0.515

High

737640

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

2

High-throughput

0.500

High

737625

SPT4
Transcription elongation factor SPT4

1

0

Small-scale

0.493

High

392418

HSP82
ATP-dependent molecular chaperone HSP82

1

13

High-throughput

0.479

High

667076

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.479

High

675815

MAS5
Mitochondrial protein import protein MAS5

1

11

High-throughput

0.479

High

737622

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.479

High

737624

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.479

High

737628

SPT10
Protein SPT10

1

3

High-throughput

0.479

High

737632

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

9

High-throughput

0.479

High

737636

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

737641

TAF4
Transcription initiation factor TFIID subunit 4

1

8

High-throughput

0.479

High

737644

APJ1
J domain-containing protein APJ1

1

11

High-throughput

0.479

High

737651

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

575273

RAD9
DNA repair protein RAD9

1

0

Small-scale

0.458

High

405058

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

381015

H2B1
Histone H2B.1

1

14

High-throughput

0.445

High

381450

H2B2
Histone H2B.2

1

14

High-throughput

0.445

High

419652

H2A2
Histone H2A.2

1

10

High-throughput

0.445

High

544173

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.445

High

737626

TFC4
Transcription factor tau 131 kDa subunit

1

7

High-throughput

0.445

High

737629

SET3
SET domain-containing protein 3

1

20

High-throughput

0.445

High

737634

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

737637

RSC8
Chromatin structure-remodeling complex protein RSC8

1

13

High-throughput

0.445

High

737642

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.445

High

737645

ARP5
Actin-related protein 5

1

7

High-throughput

0.445

High

737646

ACT
Actin

1

6

High-throughput

0.445

High

737648

CDC14
Tyrosine-protein phosphatase CDC14

1

2

High-throughput

0.445

High

737650

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.445

High

737652

DPB4
DNA polymerase epsilon subunit D

1

3

High-throughput

0.445

High

737653

ARP9
Actin-like protein ARP9

1

7

High-throughput

0.445

High

737655

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.445

High

737656

ARP8
Actin-like protein ARP8

1

9

High-throughput

0.445

High

737657

RUVB2
RuvB-like protein 2

1

8

High-throughput

0.445

High

737658

CAF1A
Chromatin assembly factor 1 subunit A

1

13

High-throughput

0.445

High

394352

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.437

High

579042

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.437

High

705629

HIBCH
Small ribosomal subunit protein mS47

1

2

High-throughput

0.437

High

737630

KMO
Kynurenine 3-monooxygenase

1

2

High-throughput

0.437

High

737643

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

737654

IES4
Ino eighty subunit 4

1

0

High-throughput

0.426

High

737638

NET1
Nucleolar protein NET1

1

2

High-throughput

0.407

High

737631

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.249

Low

574861

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025