Protein: HIRA
Protein HIRA (TUP1-like enhancer of split protein 1)

Gene: HIRA
Organism: Homo sapiens
Interactions: 120
UniProt ID: P54198

Gene Ontology (top 5):
GO:0000417 - HIR complex
GO:0000785 - chromatin
GO:0001649 - osteoblast differentiation
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926699

ASF1A
Histone chaperone ASF1A

14

17

Small-scale

0.763

High

926688

UBN1
Ubinuclein-1

8

9

Small-scale

0.755

High

926643

H33
Histone H3.3

7

20

Small-scale

0.742

High

926704

CABIN
Calcineurin-binding protein cabin-1

7

7

Small-scale

0.740

High

926690

ASF1B
Histone chaperone ASF1B

6

17

Small-scale

0.740

High

926640

H31
Histone H3.1

6

20

High-throughput

0.721

High

926651

RBBP4
Histone-binding protein RBBP4

1

17

High-throughput

0.691

High

904498

MECP2
Methyl-CpG-binding protein 2

3

10

High-throughput

0.667

High

926669

UBN2
Ubinuclein-2

3

12

Small-scale

0.656

High

926638

H4
Histone H4

3

12

Small-scale

0.640

High

371559

MYC
Myc proto-oncogene protein

3

19

Small-scale

0.633

High

517630

ZBT48
Zinc finger and BTB domain-containing protein 48

2

2

High-throughput

0.628

High

868342

CDX1
Homeobox protein CDX-1

2

2

High-throughput

0.628

High

926649

SP4
Transcription factor Sp4

2

8

High-throughput

0.628

High

926664

TEAD2
Transcriptional enhancer factor TEF-4

2

2

High-throughput

0.628

High

926665

RBBP7
Histone-binding protein RBBP7

1

19

High-throughput

0.618

High

258817

DNJA2
DnaJ homolog subfamily A member 2

2

12

Small-scale

0.611

High

926673

TLK2
Serine/threonine-protein kinase tousled-like 2

2

8

High-throughput

0.611

High

926646

TFAP4
Transcription factor AP-4

2

0

High-throughput

0.602

High

926680

ZBT10
Zinc finger and BTB domain-containing protein 10

2

6

High-throughput

0.601

High

713971

PML
Protein PML

2

13

Small-scale

0.584

High

395751

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

185552

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

13

Small-scale

0.561

High

588295

RFA2
Replication protein A 32 kDa subunit

1

7

Small-scale

0.561

High

695022

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

Small-scale

0.561

High

166137

AIM2
Interferon-inducible protein AIM2

1

5

High-throughput

0.536

High

571579

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

601605

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

849310

RANG
Ran-specific GTPase-activating protein

1

3

High-throughput

0.536

High

853949

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

866930

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

915913

PDX1
Pancreas/duodenum homeobox protein 1

1

2

High-throughput

0.536

High

926644

FOXK2
Forkhead box protein K2

1

10

High-throughput

0.536

High

926647

MEF2A
Myocyte-specific enhancer factor 2A

1

2

High-throughput

0.536

High

926668

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.536

High

926689

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.536

High

926694

DBNL
Drebrin-like protein

1

6

High-throughput

0.536

High

926695

TLK1
Serine/threonine-protein kinase tousled-like 1

1

7

High-throughput

0.536

High

256809

H2B1K
Histone H2B type 1-K

1

13

Small-scale

0.527

High

595359

H15
Histone H1.5

1

7

High-throughput

0.515

High

656081

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.515

High

926683

NKX31
Homeobox protein Nkx-3.1

1

17

High-throughput

0.515

High

926656

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.513

High

926700

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.513

High

926677

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.508

High

926697

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

0

Small-scale

0.504

High

926639

UBC9
SUMO-conjugating enzyme UBC9

1

7

Small-scale

0.501

High

926684

HIRP3
HIRA-interacting protein 3

1

3

Small-scale

0.501

High

346924

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

926650

CALD1
Caldesmon

1

20

High-throughput

0.489

High

926655

TRAF1
TNF receptor-associated factor 1

1

3

High-throughput

0.489

High

926661

SRC8
Src substrate cortactin

1

7

High-throughput

0.489

High

926637

H2B1D
Histone H2B type 1-D

1

13

Small-scale

0.481

High

926660

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

15

High-throughput

0.481

High

926678

TRI63
E3 ubiquitin-protein ligase TRIM63

1

10

High-throughput

0.481

High

926685

TRI55
Tripartite motif-containing protein 55

1

17

High-throughput

0.481

High

128884

MEN1
Menin

1

5

High-throughput

0.479

High

142909

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

209971

CRX
Cone-rod homeobox protein

1

9

High-throughput

0.479

High

213874

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

345562

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

418898

H2A1B
Histone H2A type 1-B/E

1

11

High-throughput

0.479

High

429579

JUN
Transcription factor Jun

1

14

Small-scale

0.479

High

473876

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519871

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

536819

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

538376

EGR2
E3 SUMO-protein ligase EGR2

1

2

High-throughput

0.479

High

629682

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

667232

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

775813

HNF1B
Hepatocyte nuclear factor 1-beta

1

9

High-throughput

0.479

High

776164

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

833905

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837029

ELK3
ETS domain-containing protein Elk-3

1

14

High-throughput

0.479

High

868662

LEG7
Galectin-7

1

4

Small-scale

0.479

High

881022

NASP
Nuclear autoantigenic sperm protein

1

4

High-throughput

0.479

High

883490

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

886380

CTCF
Transcriptional repressor CTCF

1

3

Small-scale

0.479

High

887862

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

903110

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

19

Small-scale

0.479

High

903292

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

919832

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

926636

KLF3
Krueppel-like factor 3

1

10

High-throughput

0.479

High

926641

GTF2I
General transcription factor II-I

1

1

Small-scale

0.479

High

926642

DCD
Dermcidin

1

2

Small-scale

0.479

High

926648

DSG1
Desmoglein-1

1

3

Small-scale

0.479

High

926652

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

Small-scale

0.479

High

926653

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

926654

TP53B
TP53-binding protein 1

1

7

High-throughput

0.479

High

926657

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

926659

CUL3
Cullin-3

1

17

Small-scale

0.479

High

926662

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.479

High

926663

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

926666

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

1

Small-scale

0.479

High

926667

RIF1
Telomere-associated protein RIF1

1

11

High-throughput

0.479

High

926670

H32
Histone H3.2

1

20

Small-scale

0.479

High

926672

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

926676

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

926682

ELF4
ETS-related transcription factor Elf-4

1

14

High-throughput

0.479

High

926686

S10AE
Protein S100-A14

1

1

High-throughput

0.479

High

926693

LHX3
LIM/homeobox protein Lhx3

1

1

High-throughput

0.479

High

926696

BAG5
BAG family molecular chaperone regulator 5

1

2

Small-scale

0.479

High

926698

RUVB1
RuvB-like 1

1

6

Small-scale

0.479

High

926701

CDIN1
CDAN1-interacting nuclease 1

1

1

High-throughput

0.479

High

926703

ETV7
Transcription factor ETV7

1

10

High-throughput

0.479

High

168217

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

370283

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

926645

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

926671

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.458

High

926674

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

926702

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.458

High

344141

PTBP3
Polypyrimidine tract-binding protein 3

1

10

High-throughput

0.445

High

926658

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.445

High

926681

CDC5L
Cell division cycle 5-like protein

1

13

High-throughput

0.445

High

926691

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

649722

SPR1B
Cornifin-B

1

1

High-throughput

0.437

High

328811

CSPG5
Chondroitin sulfate proteoglycan 5

2

0

High-throughput

0.313

High

926687

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

926675

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

926679

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

Small-scale

0.249

Low

926692

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025