Protein: HIR2
Protein HIR2 (Histone transcription regulator 2)

Gene: HIR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P32480

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000417 - HIR complex
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

737621

HIR1
Protein HIR1

7

16

Small-scale

0.963

High

736615

ASF1
Histone chaperone ASF1

8

16

Small-scale

0.747

High

737682

HPC2
Histone promoter control protein 2

5

7

Small-scale

0.716

High

737678

HIR3
Histone transcription regulator 3

4

3

Small-scale

0.694

High

381951

H4
Histone H4

4

10

Small-scale

0.672

High

737680

H3
Histone H3

4

20

Small-scale

0.672

High

737673

RT106
Histone chaperone RTT106

3

2

Small-scale

0.660

High

523368

HSP71
Heat shock protein SSA1

2

15

High-throughput

0.611

High

737677

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

392419

HSP82
ATP-dependent molecular chaperone HSP82

2

13

High-throughput

0.571

High

737661

HSP7F
Heat shock protein homolog SSE1

2

20

High-throughput

0.571

High

737665

SPT10
Protein SPT10

2

2

High-throughput

0.571

High

737672

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

419386

H2A1
Histone H2A.1

1

8

High-throughput

0.536

High

544174

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.536

High

614807

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

9

Small-scale

0.515

High

643614

SNF2
Transcription regulatory protein SNF2

1

17

Small-scale

0.515

High

737662

SWI3
SWI/SNF complex subunit SWI3

1

7

Small-scale

0.515

High

394353

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.479

High

647725

RFA1
Replication factor A protein 1

1

7

Small-scale

0.479

High

667077

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.479

High

675816

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.479

High

706507

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

734392

BTAF1
TATA-binding protein-associated factor MOT1

1

20

Small-scale

0.479

High

737663

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.479

High

737666

CENPA
Histone H3-like centromeric protein CSE4

1

20

Small-scale

0.479

High

737679

TAF4
Transcription initiation factor TFIID subunit 4

1

3

High-throughput

0.479

High

737675

DLS1
Protein DLS1

1

0

High-throughput

0.458

High

737683

UBC7
Ubiquitin-conjugating enzyme E2 7

1

8

High-throughput

0.457

High

381016

H2B1
Histone H2B.1

1

15

High-throughput

0.445

High

419653

H2A2
Histone H2A.2

1

8

High-throughput

0.445

High

526181

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

670469

SIS1
Protein SIS1

1

12

High-throughput

0.445

High

737667

SET3
SET domain-containing protein 3

1

15

High-throughput

0.445

High

737670

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

737671

MBP1
Transcription factor MBP1

1

5

High-throughput

0.445

High

737674

ATAD2
ATPase histone chaperone YTA7

1

7

High-throughput

0.445

High

737676

DJP1
DnaJ-like protein 1

1

13

High-throughput

0.445

High

737681

SEN1
Helicase SEN1

1

8

Small-scale

0.445

High

737684

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

737687

CAF1A
Chromatin assembly factor 1 subunit A

1

10

High-throughput

0.445

High

737668

KMO
Kynurenine 3-monooxygenase

1

2

High-throughput

0.437

High

448151

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

737660

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

737685

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

737664

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

737669

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

4

High-throughput

0.407

High

737686

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High


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Last updated: 11Aug2025