HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 23770852, 23911321, 27705803, 30728155, 9827542, 11099048, 10531035, 33961781, 34080260, 15452136, 19270694, 22524983, 26087183, 26474281, 28614300, 29137415, 27220724, 29499133, 30254149, 29997244 and 30 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, x-ray crystallography, fluorescent resonance energy transfer, molecular sieving, anti tag coimmunoprecipitation, coimmunoprecipitation, anti bait coimmunoprecipitation, split luciferase complementation and 3 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024