Protein: LYOX
Protein-lysine 6-oxidase (EC 1.4.3.13) (Lysyl oxidase) [Cleaved into: Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form]

Gene: LYOX, LOX
Organism: Homo sapiens
Interactions: 62
UniProt ID: P28300

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0004720 - protein-lysine 6-oxidase activity
GO:0005507 - copper ion binding
GO:0005518 - collagen binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584616

ELN
Elastin

3

5

Small-scale

0.670

High

389064

FINC
Fibronectin

3

3

Small-scale

0.661

High

702205

LOXL2
Lysyl oxidase homolog 2

1

2

Small-scale

0.647

High

351505

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

9

Small-scale

0.646

High

702174

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

2

6

Small-scale

0.624

High

400327

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

Small-scale

0.595

High

516028

CSH1
Chorionic somatomammotropin hormone 1

1

5

Small-scale

0.586

High

516040

CSH2
Chorionic somatomammotropin hormone 2

1

5

Small-scale

0.586

High

702201

FBLN5
Fibulin-5

2

9

Small-scale

0.576

High

376584

EGF
Pro-epidermal growth factor

1

3

Small-scale

0.536

High

388608

C1QA
Complement C1q subcomponent subunit A

1

3

High-throughput

0.536

High

702175

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

366333

PLMN
Plasminogen

1

0

Small-scale

0.513

High

702182

DERM
Dermatopontin

1

0

Small-scale

0.513

High

377149

PRL
Prolactin

1

5

Small-scale

0.501

High

377179

SOMA
Somatotropin

1

5

Small-scale

0.501

High

469664

MMP2
72 kDa type IV collagenase

1

5

Small-scale

0.501

High

551762

CO6A1

1

1

Small-scale

0.501

High

642514

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

3

Small-scale

0.501

High

702186

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

8

Small-scale

0.501

High

702189

H2B2E
Histone H2B type 2-E

1

2

Small-scale

0.501

High

702197

ANTR1
Anthrax toxin receptor 1

1

1

Small-scale

0.501

High

534679

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.489

High

702187

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.489

High

516154

HS71A
Heat shock 70 kDa protein 1A

1

4

Small-scale

0.479

High

635235

EFNA1
Ephrin-A1

1

4

High-throughput

0.479

High

702178

EFNA4
Ephrin-A4

1

4

High-throughput

0.479

High

702180

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

4

Small-scale

0.479

High

302245

STC2
Stanniocalcin-2

1

0

Small-scale

0.458

High

424584

PAI1
Plasminogen activator inhibitor 1

1

0

Small-scale

0.458

High

702181

H11
Histone H1.1

1

2

Small-scale

0.457

High

384119

CO1A1
Collagen alpha-1(I) chain

1

2

Small-scale

0.457

High

384282

CO3A1

1

2

Small-scale

0.457

High

465941

CO1A2
Collagen alpha-2(I) chain

1

2

Small-scale

0.457

High

702191

ATL4
ADAMTS-like protein 4

1

4

Small-scale

0.457

High

371236

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.445

High

702203

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.438

High

217862

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

330681

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

702177

EFNA3
Ephrin-A3

1

4

High-throughput

0.437

High

702179

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

702196

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

Small-scale

0.437

High

702206

CD2AP
CD2-associated protein

1

1

Small-scale

0.437

High

702185

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.417

High

702193

P66B
Transcriptional repressor p66-beta

1

2

Small-scale

0.417

High

702194

AP2C
Transcription factor AP-2 gamma

1

2

High-throughput

0.417

High

702188

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

Small-scale

0.305

High

61432

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.279

Low

124894

GTPB1
GTP-binding protein 1

1

0

High-throughput

0.279

Low

693240

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.279

Low

702184

PDE7A
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

1

0

High-throughput

0.279

Low

702190

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.279

Low

702195

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.279

Low

702198

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.279

Low

702199

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.279

Low

702202

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

702192

DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

1

0

Small-scale

0.265

Low

702176

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.261

Low

651166

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.249

Low

702183

SOS2
Son of sevenless homolog 2

1

0

Small-scale

0.238

Low

702200

UXT
Protein UXT

1

0

Small-scale

0.238

Low

702204

MEMO1
Protein MEMO1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025