HitPredict

Interactor 1: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Interactor 2: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.830

The method score is based on:

Property Details
Experiments 9452483, 32814053, 37776851
Identification Methods affinity chromatography technology, validated two hybrid, two hybrid array, two hybrid pooling approach, cross-linking study
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB_C, AAA_lid_3~AAA_lid_3, AAA~CDC48_2, AAA_lid_3~CDC48_2, AAA~CDC48_N, AAA_lid_3~CDC48_N
Common GO terms GO:0000502 - proteasome complex
GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 3 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 806
Hs

1 440
+ Dm
+ Hs
+ At
+ Hs
+ Hs
+ Sc
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs
+ Sc

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Last updated: 11Aug2025