HitPredict

Interactor 1: PAR2 (P55085)
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Gene: F2RL1

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28298427
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 397 Hs			1 236
+	Hs
		907084 CCR9_HUMAN (72-396): 2.49e-79: 250: 24.48		CD81_HUMAN (1-236): 1.96e-63: 199: 100.00
+	Hs
		835573 CCR9_HUMAN (72-396): 2.49e-79: 250: 24.48		TSN7_HUMAN (1-234): 1.4e-56: 182: 22.31
+	Hs
		458357 ADRB2_HUMAN (42-383): 4.3e-72: 232: 15.08		CD81_HUMAN (1-236): 1.96e-63: 199: 100.00
+	Hs
		936108 PAR2_HUMAN (1-374): 4.98e-74: 237: 100.00		TSN17_HUMAN (8-235): 1.18e-55: 180: 21.37
+	Hs
		835475 CCR2_HUMAN (57-362): 2.25e-66: 217: 24.44		CD81_HUMAN (1-236): 1.96e-63: 199: 100.00
+	Hs
		458315 ADRB2_HUMAN (42-383): 4.3e-72: 232: 15.08		TSN7_HUMAN (1-234): 1.4e-56: 182: 22.31
+	Hs
		477412 PAR2_HUMAN (1-374): 4.98e-74: 237: 100.00		CD63_HUMAN (1-232): 1.05e-52: 172: 22.95
+	Hs
		458278 ADRB2_HUMAN (42-383): 4.3e-72: 232: 15.08		CD9_HUMAN (1-234): 7.49e-54: 174: 43.59
+	Hs
		349396 CCR6_HUMAN (72-394): 2.92e-78: 247: 23.57		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48
+	Hs
		835471 CCR2_HUMAN (57-362): 2.25e-66: 217: 24.44		TSN7_HUMAN (1-234): 1.4e-56: 182: 22.31
+	Hs
		221444 OX2R_HUMAN (23-383): 5.08e-75: 241: 19.36		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48
+	Hs
		349382 NK3R_HUMAN (40-395): 4.09e-72: 234: 18.53		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48
+	Hs
		349385 AGTR1_HUMAN (48-391): 6.61e-72: 231: 24.29		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48
+	Hs
		535911 AGTR1_HUMAN (48-391): 6.61e-72: 231: 24.29		CD37_HUMAN (2-232): 1.97e-44: 152: 20.00
+	Hs
		349415 GPR17_HUMAN (57-385): 5.5e-65: 213: 28.06		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48
+	Hs
		349390 LPAR6_HUMAN (81-356): 6.84e-35: 133: 30.28		TSN15_HUMAN (10-230): 2.63e-44: 152: 15.48