HitPredict

Interactor 1: HDAC2 (P70288)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)
Gene: HDAC2

Interactor 2: Q60I23 (Q60I23)
SRY (sex determining region Y)-box 2 (Sox2 protein) (Transcriptional factor SOX2)
Gene: Sox2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	0.60	0.484

Property	Details
Experiments	21532573
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Mm			1 319
+	Hs
		818314 HDAC2_HUMAN (1-488): 0: 707: 99.39		SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24
+	Mm
		818688 HDAC2_MOUSE (1-488): 0: 706: 100.00		SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43
+	Mm
		140273 HDAC1_MOUSE (1-446): 0: 647: 89.46		Q60I23_MOUSE (1-319): 7.44e-64: 206: 100.00
+	Mm
		140241 HDAC1_MOUSE (1-446): 0: 647: 89.46		SOX2_MOUSE (1-319): 1.13e-62: 203: 98.43
+	Hs
		1270390 HDAC2_HUMAN (1-488): 0: 707: 99.39		CIC_HUMAN (10-274): 1.46e-36: 141: 24.28
+	Hs
		818023 HDAC1_HUMAN (1-446): 0: 643: 89.24		SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24
+	Hs
		727903 HDAC2_HUMAN (1-488): 0: 707: 99.39		SOX6_HUMAN (18-202): 1.01e-33: 132: 29.73
+	Hs
		331858 HDAC2_HUMAN (1-488): 0: 707: 99.39		NSD2_HUMAN (1-250): 1.25e-27: 115: 11.83
+	Hs
		1270484 HDAC2_HUMAN (1-488): 0: 707: 99.39		HM20B_HUMAN (6-159): 4.8e-28: 112: 23.38
+	Hs
		1038645 HDAC1_HUMAN (1-446): 0: 643: 89.24		CIC_HUMAN (10-274): 1.46e-36: 141: 24.28
+	Hs
		727863 HDAC1_HUMAN (1-446): 0: 643: 89.24		SOX6_HUMAN (18-202): 1.01e-33: 132: 29.73
+	Hs
		1038578 HDAC1_HUMAN (1-446): 0: 643: 89.24		BBX_HUMAN (31-257): 3.4e-33: 131: 20.78
+	Hs
		883315 HDAC1_HUMAN (1-446): 0: 643: 89.24		SOX8_HUMAN (12-312): 3.61e-33: 128: 26.23
+	Mm
		140296 HDAC1_MOUSE (1-446): 0: 647: 89.46		NSD2_MOUSE (4-250): 6.03e-29: 119: 10.32
+	Hs
		297491 HDAC1_HUMAN (1-446): 0: 643: 89.24		TOX4_HUMAN (9-316): 7.19e-28: 115: 12.14
+	Hs
		331809 HDAC1_HUMAN (1-446): 0: 643: 89.24		NSD2_HUMAN (1-250): 1.25e-27: 115: 11.83
+	Hs
		1038764 HDAC1_HUMAN (1-446): 0: 643: 89.24		HM20B_HUMAN (6-159): 4.8e-28: 112: 23.38
+	Dm
		1098074 HDAC1_DROME (5-472): 0: 654: 77.71		HMG2_DROME (29-164): 2.67e-13: 71.7: 13.01
+	Mm
		57643 HDAC1_MOUSE (1-446): 0: 647: 89.46		A2AWT7_MOUSE (1-126): 8.82e-11: 64.8: 17.83
+	Hs
		177214 HDAC3_HUMAN (10-431): 0: 575: 58.02		SOX6_HUMAN (18-202): 1.01e-33: 132: 29.73