Protein: DEP1B
DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8)

Gene: DEP1B, DEPDC1B
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q8WUY9

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0016477 - cell migration
GO:0030177 - positive regulation of Wnt signaling pathway
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375772

RASK
GTPase KRas

3

11

High-throughput

0.739

High

1357434

ARHGC
Rho guanine nucleotide exchange factor 12

2

9

High-throughput

0.737

High

374096

RASN
GTPase NRas

2

11

High-throughput

0.675

High

901970

RAB9A
Ras-related protein Rab-9A

2

4

High-throughput

0.675

High

978198

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.675

High

1328545

NGEF
Ephexin-1

2

7

High-throughput

0.659

High

269589

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

14

High-throughput

0.618

High

466385

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

953588

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962319

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

988564

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1257025

SYDE1
Rho GTPase-activating protein SYDE1

1

15

High-throughput

0.618

High

1357426

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1357446

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

7

High-throughput

0.618

High

966669

1433G
14-3-3 protein gamma

3

20

High-throughput

0.604

High

854700

RAGP1
Ran GTPase-activating protein 1

2

2

High-throughput

0.571

High

903431

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

5

High-throughput

0.571

High

1357441

CDC23
Cell division cycle protein 23 homolog

2

3

Small-scale

0.560

High

126719

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.553

High

318832

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.553

High

341115

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.553

High

374807

RASH
GTPase HRas

1

8

High-throughput

0.553

High

463675

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.553

High

581197

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.553

High

601389

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

630593

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.553

High

630908

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.553

High

631373

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.553

High

773581

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.553

High

900951

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.553

High

910147

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.553

High

921972

COPA
Coatomer subunit alpha

1

2

High-throughput

0.553

High

955418

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.553

High

956423

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.553

High

962794

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.553

High

976450

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.553

High

1015633

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.553

High

1104231

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

4

High-throughput

0.553

High

1145037

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.553

High

1151798

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.553

High

1216078

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.553

High

1227146

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.553

High

1270921

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.553

High

1357399

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.553

High

1357406

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1357418

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.553

High

1357422

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

971825

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.536

High

540588

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.533

High

522706

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

2

Small-scale

0.527

High

173136

XPO1
Exportin-1

2

17

High-throughput

0.521

High

321607

PRP6
Pre-mRNA-processing factor 6

2

2

High-throughput

0.521

High

442419

GELS
Gelsolin

2

1

High-throughput

0.521

High

451227

NFL
Neurofilament light polypeptide

2

8

High-throughput

0.521

High

876621

NEST
Nestin

2

15

High-throughput

0.521

High

890374

NU153
Nuclear pore complex protein Nup153

2

5

High-throughput

0.521

High

1134659

NUMA1
Nuclear mitotic apparatus protein 1

2

9

High-throughput

0.521

High

1280362

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

5

High-throughput

0.521

High

1323422

NUP93
Nuclear pore complex protein Nup93

2

3

High-throughput

0.521

High

1341275

COQ8A
Atypical kinase COQ8A, mitochondrial

2

1

High-throughput

0.521

High

1357405

ZFR
Zinc finger RNA-binding protein

2

1

High-throughput

0.521

High

1357413

PKP2
Plakophilin-2

2

5

High-throughput

0.521

High

1357429

SMC4
Structural maintenance of chromosomes protein 4

2

2

High-throughput

0.521

High

990539

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.489

High

1022435

IDD
Integral membrane protein DGCR2/IDD

1

2

High-throughput

0.489

High

1049607

1433F
14-3-3 protein eta

1

20

High-throughput

0.489

High

1093015

CDC16
Cell division cycle protein 16 homolog

1

3

High-throughput

0.489

High

1357402

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.489

High

1357403

BSCL2
Seipin

1

1

High-throughput

0.489

High

1357452

BACE2
Beta-secretase 2

1

2

High-throughput

0.489

High

890670

RGS3
Regulator of G-protein signaling 3

1

3

Small-scale

0.481

High

1357450

GRIP1
Glutamate receptor-interacting protein 1

1

9

Small-scale

0.481

High

176857

DCLK1
Serine/threonine-protein kinase DCLK1

1

7

High-throughput

0.479

High

208711

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

245256

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.479

High

247395

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

648606

FGFR4
Fibroblast growth factor receptor 4

1

15

High-throughput

0.479

High

710396

EPHA2
Ephrin type-A receptor 2

1

12

High-throughput

0.479

High

1357440

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

1347589

UHMK1
Serine/threonine-protein kinase Kist

1

2

Small-scale

0.439

High

174014

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.437

High

188697

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

Small-scale

0.437

High

211003

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.437

High

218539

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

242405

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.437

High

243686

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

5

High-throughput

0.437

High

252128

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.437

High

281383

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.437

High

367602

CAH2
Carbonic anhydrase 2

1

2

High-throughput

0.437

High

412322

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

418302

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

457892

INVO
Involucrin

1

1

High-throughput

0.437

High

472921

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.437

High

562268

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.437

High

582897

EZRI
Ezrin

1

6

High-throughput

0.437

High

604125

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.437

High

605759

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.437

High

642991

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

701877

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.437

High

715692

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.437

High

719248

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.437

High

733965

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

2

High-throughput

0.437

High

764914

CTNB1
Catenin beta-1

1

6

Small-scale

0.437

High

767476

RADI
Radixin

1

6

High-throughput

0.437

High

786185

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.437

High

820700

CEAM6
Cell adhesion molecule CEACAM6

1

2

High-throughput

0.437

High

832930

CETN2
Centrin-2

1

2

High-throughput

0.437

High

845739

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.437

High

853496

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

4

Small-scale

0.437

High

934123

XPO2
Exportin-2

1

16

High-throughput

0.437

High

936399

AFAD
Afadin

1

10

High-throughput

0.437

High

937304

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

3

High-throughput

0.437

High

945826

EPIPL
Epiplakin

1

3

High-throughput

0.437

High

975148

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.437

High

1004144

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.437

High

1041199

CAV1
Caveolin-1

1

2

High-throughput

0.437

High

1042035

LMNB2
Lamin-B2

1

6

High-throughput

0.437

High

1109179

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.437

High

1128244

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.437

High

1129665

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.437

High

1131785

LBR
Delta(14)-sterol reductase LBR

1

3

High-throughput

0.437

High

1134017

ZN638
Zinc finger protein 638

1

4

High-throughput

0.437

High

1143206

PLEC
Plectin

1

4

High-throughput

0.437

High

1159774

OCLN
Occludin

1

2

High-throughput

0.437

High

1203576

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.437

High

1210491

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.437

High

1229895

AN34A
Ankyrin repeat domain-containing protein 34A

1

8

High-throughput

0.437

High

1233383

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1235305

STYK1
Tyrosine-protein kinase STYK1

1

17

High-throughput

0.437

High

1238754

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1291089

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.437

High

1309230

KSR1
Kinase suppressor of Ras 1

1

9

High-throughput

0.437

High

1322917

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1333918

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.437

High

1349463

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1352597

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.437

High

1353233

PARD3
Partitioning defective 3 homolog

1

10

High-throughput

0.437

High

1357396

SRS12
Serine/arginine-rich splicing factor 12

1

5

High-throughput

0.437

High

1357397

LAR4B
La-related protein 4B

1

3

High-throughput

0.437

High

1357398

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.437

High

1357401

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1357404

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1357409

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

14

High-throughput

0.437

High

1357411

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.437

High

1357412

RBM15
RNA-binding protein 15

1

3

High-throughput

0.437

High

1357414

DDX50
ATP-dependent RNA helicase DDX50

1

7

High-throughput

0.437

High

1357415

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1357416

RTKN
Rhotekin

1

1

High-throughput

0.437

High

1357421

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.437

High

1357423

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1357424

GHC1
Mitochondrial glutamate carrier 1

1

5

High-throughput

0.437

High

1357425

SFXN1
Sideroflexin-1

1

1

High-throughput

0.437

High

1357428

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.437

High

1357430

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.437

High

1357433

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.437

High

1357436

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.437

High

1357437

ANFY1
Rabankyrin-5

1

6

High-throughput

0.437

High

1357439

DNJ5B
DnaJ homolog subfamily C member 5B

1

2

High-throughput

0.437

High

1357443

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.437

High

1357444

ZBT21
Zinc finger and BTB domain-containing protein 21

1

13

High-throughput

0.437

High

1357445

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.437

High

1357447

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.437

High

1357449

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

1357451

KCTD3
BTB/POZ domain-containing protein KCTD3

1

4

High-throughput

0.437

High

1357454

COPG1
Coatomer subunit gamma-1

1

9

High-throughput

0.437

High

561136

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.347

High

283320

ERLN1
Erlin-1

2

0

High-throughput

0.298

High

1357453

RT18B
Small ribosomal subunit protein mS40

2

0

High-throughput

0.298

High

1357417

EBPL
Emopamil-binding protein-like

1

0

High-throughput

0.282

High

1337287

ACRBP
Acrosin-binding protein

1

0

High-throughput

0.279

Low

1357419

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.279

Low

1357442

APC4
Anaphase-promoting complex subunit 4

1

0

High-throughput

0.279

Low

139944

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

189740

STX7
Syntaxin-7

1

0

High-throughput

0.249

Low

257914

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.249

Low

327380

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

519176

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

880626

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1025575

CDK16
Cyclin-dependent kinase 16

1

0

High-throughput

0.249

Low

1258298

MOB2
MOB kinase activator 2

1

0

High-throughput

0.249

Low

1289485

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1293094

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1357400

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.249

Low

1357407

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.249

Low

1357408

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

1357410

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1357420

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1357427

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

Small-scale

0.249

Low

1357431

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1357432

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1357435

SEP10
Septin-10

1

0

High-throughput

0.249

Low

1357438

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1357448

RUVB1
RuvB-like 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025