HitPredict

Interactor 1: EZH1 (P70351)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Interactor 2: RBBP4 (Q60972)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25680957, 20064376
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 747 Mm			1 425
+	Hs
		997839 EZH1_HUMAN (1-747): 0: 841: 97.86		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		1083337 EZH1_HUMAN (1-747): 0: 841: 97.86		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		936647 EZH1_MOUSE (1-747): 0: 842: 100.00		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Mm
		1141929 EZH2_MOUSE (8-746): 0: 708: 63.29		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		997735 EZH2_HUMAN (8-746): 0: 704: 63.03		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141935 Q6AXH7_MOUSE (8-746): 0: 684: 62.48		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141957 EZH2_MOUSE (8-746): 0: 708: 63.29		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		1079986 EZH2_HUMAN (8-746): 0: 704: 63.03		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		1141960 Q6AXH7_MOUSE (8-746): 0: 684: 62.48		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		267764 EZH2_HUMAN (8-746): 0: 704: 63.03		TAF5L_HUMAN (26-422): 3e-74: 244: 22.20
+	Dm
		785628 EZ_DROME (8-747): 0: 692: 49.56		CAF1_DROME (226-419): 3.68e-29: 119: 18.36
+	Mm
		1141954 EHMT2_MOUSE (443-733): 5.54e-68: 246: 24.16		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		203672 SUV91_HUMAN (397-732): 1.58e-73: 246: 22.19		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	At
		187006 CLF_ARATH (137-734): 5.84e-108: 351: 26.26		MSI4_ARATH (5-415): 2.7e-81: 260: 31.11
+	Hs
		203695 SUV91_HUMAN (397-732): 1.58e-73: 246: 22.19		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	At
		186924 CLF_ARATH (137-734): 5.84e-108: 351: 26.26		MSI1_ARATH (2-210): 3.43e-31: 125: 13.22
+	At
		186920 MEDEA_ARATH (356-734): 1.12e-98: 321: 33.42		MSI1_ARATH (2-210): 3.43e-31: 125: 13.22
+	At
		186949 EZA1_ARATH (333-734): 4.63e-95: 316: 32.32		MSI1_ARATH (2-210): 3.43e-31: 125: 13.22
+	Dm
		1099178 ASH1_DROME (179-733): 3.51e-88: 306: 18.05		CAF1_DROME (226-419): 3.68e-29: 119: 18.36
+	Hs
		203735 SUV91_HUMAN (397-732): 1.58e-73: 246: 22.19		DAW1_HUMAN (9-106): 2.42e-20: 94.1: 8.74