Protein: KDM4C
Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)

Gene: KDM4C
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q9H3R0

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001825 - blastocyst formation
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273453

KDM4A
Lysine-specific demethylase 4A

1

15

Small-scale

0.618

High

1432849

KDM4C
Lysine-specific demethylase 4C

1

16

Small-scale

0.618

High

414615

P53
Cellular tumor antigen p53

1

4

Small-scale

0.578

High

1161394

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.537

High

65815

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

1

High-throughput

0.536

High

370361

CYTA
Cystatin-A

1

1

High-throughput

0.536

High

623539

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.536

High

714966

EF1D
Elongation factor 1-delta

1

3

High-throughput

0.536

High

788202

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

854740

RAGP1
Ran GTPase-activating protein 1

1

2

High-throughput

0.536

High

941555

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.536

High

977082

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.536

High

1088744

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.536

High

1090537

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.536

High

1095225

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

1

High-throughput

0.536

High

1116452

FHL1
Four and a half LIM domains protein 1

1

2

High-throughput

0.536

High

1149192

SF3A1
Splicing factor 3A subunit 1

1

3

High-throughput

0.536

High

1217196

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.536

High

224796

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

367612

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.513

High

616367

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.513

High

648229

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.513

High

659837

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.513

High

697251

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.513

High

761027

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.513

High

941263

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

984542

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

992650

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.513

High

998802

H31
Histone H3.1

1

20

Small-scale

0.501

High

1258941

H32
Histone H3.2

1

20

Small-scale

0.501

High

361820

PNPH
Purine nucleoside phosphorylase

1

1

High-throughput

0.489

High

539009

EPB41
Protein 4.1

1

2

High-throughput

0.489

High

657395

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.489

High

665494

EF1B
Elongation factor 1-beta

1

3

High-throughput

0.489

High

699121

CALX
Calnexin

1

1

High-throughput

0.489

High

877384

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.489

High

1051860

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.489

High

1124719

SRC8
Src substrate cortactin

1

2

High-throughput

0.489

High

1412143

ERP44
Endoplasmic reticulum resident protein 44

1

3

High-throughput

0.489

High

1432187

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

2

High-throughput

0.489

High

1432850

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.489

High

188365

HDAC3
Histone deacetylase 3

1

13

Small-scale

0.479

High

316991

MTA2
Metastasis-associated protein MTA2

1

3

High-throughput

0.479

High

562647

RINI
Ribonuclease inhibitor

1

1

Small-scale

0.479

High

566036

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

789571

PPARG
Peroxisome proliferator-activated receptor gamma

1

16

Small-scale

0.479

High

991099

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

Small-scale

0.479

High

1017205

H33
Histone H3.3

1

20

Small-scale

0.479

High

1110075

HDAC1
Histone deacetylase 1

1

14

Small-scale

0.479

High

1141930

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

1338369

FBX22
F-box only protein 22

1

3

Small-scale

0.479

High

1371528

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

Small-scale

0.479

High

647656

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

Small-scale

0.458

High

810372

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

129805

CBX4
E3 SUMO-protein ligase CBX4

1

10

Small-scale

0.445

High

474979

VIME
Vimentin

1

2

Small-scale

0.437

High

249200

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

359737

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.279

Low

932941

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1295213

HOME1
Homer protein homolog 1

1

0

High-throughput

0.279

Low

1407343

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

160615

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.249

Low

516953

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025