HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: KPCD (Q05655)
Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]
Gene: PRKCD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	23371553, 26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase, C1_1~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0106310 - protein serine kinase activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 676
+	Hs
		984533 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		KPCD_HUMAN (1-676): 0: 790: 100.00
+	Hs
		623870 RIPK4_HUMAN (1-832): 0: 726: 100.00		KPCL_HUMAN (22-671): 0: 684: 42.88
+	Hs
		623883 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		KPCL_HUMAN (22-671): 0: 684: 42.88
+	Hs
		408584 RIPK4_HUMAN (1-832): 0: 726: 100.00		KPCB_HUMAN (124-287): 1.64e-44: 171: 42.07
+	Hs
		783961 RIPK4_HUMAN (1-832): 0: 726: 100.00		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		408681 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		KPCB_HUMAN (124-287): 1.64e-44: 171: 42.07
+	Hs
		784088 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		784002 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		983830 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		KPCZ_HUMAN (66-231): 1.99e-35: 143: 19.19